摘要
Abstract
Heart failure is the terminal outcome of cardiovascular disease.Endoplasmic reticulum stress is an endogenous integrated regulatory mechanism of the endoplasmic reticulum under the stimulation of negative factors,which can promote or inhibit apoptosis of cardiomyocytes and is the pathophysiological basis of the onset of heart failure.This study focuses on the Qi(气)and blood theory and endoplasmic reticulum stress to elaborate on the pathological mechanism of heart failure and the intervention effect of traditional Chinese medicine on heart failure by targeting endoplasmic reticulum stress.The pathological state of Qi-blood and Yin(阴)-Yang(阳)imbalance runs through the entire course of heart failure,and the regulation of endoplasmic reticulum stress is highly consistent with the state of Qi-blood balance,which is the manifestation of the theory of Qi and blood at the microscopic level.The harmony of Qi and blood can resist pathogenic factors,and moderate endoplasmic reticulum stress can achieve the purposes of self-regulation and repair,and maintain the normal cardiac function.The harmony of Qi and blood is the manifestation of Yin-Yang balance in the human body and the normal function of internal organs.Abundant Qi promotes the circulation of blood,and sufficient blood carries Qi throughout the body.The imbalance of Qi and blood leads to Qi deficiency and blood stasis,aggravating heart failure.Excessive endoplasmic reticulum stress causes myocardial cell hypertrophy,damage,and apoptosis,promoting the progression of heart failure.The imbalance of Qi and blood leads to Qi deficiency and blood circulation weakness,resulting in blood stasis.Blood stasis inhibits Qi circulation,which causes the rise and fall disorder of Qi circulation,resulting in the occurrence of diseases.Targeting regulation of endoplasmic reticulum stress in myocardial cells through the method of tonifying Qi,promoting blood circulation,and removing blood stasis is the key to preventing and treating heart failure.Regulating endoplasmic reticulum stress with Chinese medicines to prevent the progression of heart failure is promising.For example,Chinese medicines with the function of"tonifying Qi"such as Renshen(Radix Ginseng),Huangqi(Radix Astragali),and Gegen(Radix Puerariae Lobatae),as well as Chinese medicines with the function of"promoting blood circulation"such as Hongjingtian(Rhodiola rosea)and Danshen(Radix et Rhizoma Salviae Miltiorrhizae),all can be used to regulate endoplasmic reticulum stress.Additionally,Chinese medicine compound prescriptions such as the Buzhong Yiqi decoction(补中益气汤),the Buyang Huanwu decoction(补阳还五汤),and the Xuefu Zhuyu decoction(血府逐瘀汤)can also be used to regulate endoplasmic reticulum stress.This study is based on the theory of Qi-blood and Yin-Yang,follows the method of tonifying Qi,promoting blood circulation,and removing blood stasis,and takes therapeutic advantages of the multi-target and multi-pathway of Chinese medicines to regulate endoplasmic reticulum stress,thereby maintaining the stability of cardiac function,which is of great significance for the treatment of heart failure.关键词
内质网应激/心力衰竭/气血理论/补气活血化瘀Key words
Endoplasmic reticulum stress/Heart failure/Qi and blood theory/Invigorating Qi and activating blood circulation,to remove blood stasis分类
医药卫生
