中医临床研究2025，Vol.17Issue(21)：57-63,7.DOI:10.3969/j.issn.1674-7860.2025.21.010
基于古代文献探析不寐的组方用药规律
An analysis of medication rules of prescriptions for treating insomnia based on ancient medical literature
摘要
Abstract
Objective:To use mining technology to systematically analyze the medication rules of prescriptions for treating insomnia in the ancient literature,and to extract the clinical medication experience and compatibility characteristics of the included prescriptions,so as to provide theoretical basis and new ideas for the treatment of insomnia in modern times.Through the integration of traditional Chinese medicine theory and modern data analysis methods,we will further promote the integrated development of integrated traditional Chinese and Western medicine in the field of insomnia treatment,help the formulation of personalized medical plans,the research and development of new traditional Chinese medicine compounds,and the optimization and upgrading of existing treatment strategies.At the same time,we hope to reveal the traditional drugs or compatibility modes that may be ignored by the modern medical system,provide directions for exploring the potential pathological mechanisms and treatment targets of insomnia,and ultimately provide more safe,effective and TCM featured interventions for the majority of patients with insomnia.Methods:Keywords such as sleepless,inability to close eyes,imcapability of supination,and restless sleep in Chinese Medical Canon were searched,and a relevant database was established by the Microsoft Excel 2019 after screening keywords.The traditional Chinese medicine inheritance computer system V3.0 was used for data mining to analyze the medicinal flavor,medicinal property,tropism meridian,efficacy,used frequency,and high frequency medicine combination of prescriptions included,and the association rule analysis and cluster analysis were carried out.Results:A total of 257 prescriptions for the treatment of insomnia were included,involving 296 Chinese medicines.Among them,31 Chinese medicinals were used more than 20 times,mainly including Fuling(Poria),Suanzaoren(Semen Ziziphi Spinosae),Banxia(Rhizoma Pinelliae),Gancao(Radix Glycyrrhizae),Danggui(Radix Angelicae Sinensis),Fushen(Sclerotium Poriae Circum Radicem Pint),etc.According to the classification of efficacy of Chinese medicinals,most of them were tonic medicines,heat-clearing medicines,diuretic and damp-removing medicines.The medicinal properties were mainly warm,cold,and moderate,and the medicinal tastes were mainy sweet,bitter,and pungency.The main meridians involved were spleen meridian,lung meridian,heart meridian,stomach meridian,and liver meridian.The medicine combination with the highest frequency was Suanzaoren-Fushen.A total of 18 high-frequency medicine combinations,7 association rules of Chinese medicinals,and 3 new prescriptions were obtained finally.Conclusion:In the treatment of insomnia,ancient physicians comprehensively used the methods of tonifying,clearing heat,clearing damp and promoting diuresis,resolving phlegm and calming nerves,forming a comprehensive and multi-level treatment system,which has important enlightenment and reference value for modern clinical treatment of insomnia.关键词
不寐/失眠/《中华医典》/数据挖掘/用药规律Key words
Sleeplessness/Insomnia/Chinese Medical Canon/Data mining/Medication rule分类
医药卫生引用本文复制引用
赵志鹏,隋晓琳,刘相静,牛天芹,王安逸,郭玉梦,周政,张宪忠..基于古代文献探析不寐的组方用药规律[J].中医临床研究,2025,17(21):57-63,7.基金项目
第七批全国老中医药专家学术经验工作项目(国中医药人教函[2022]76号). （国中医药人教函[2022]76号）
