遵义医科大学学报2025，Vol.48Issue(9)：938-944,952,8.
基于哈顿模型的耐多药肺结核不良治疗转归的临床特征及影响因素分析
Analysis of clinical characteristics and influencing factors of adverse treatment outcome of multidrug-resistant pulmonary tuberculosis based on Hatton model
摘要
Abstract
Objective To explore the clinical characteristics of adverse treatment outcomes of multidrug-resistant tuberculosis(MDR-TB),and to analyze its influencing factors based on the theoretical framework of the Hatton model,in order to provide a basis for optimizing treatment strategies.Methods The clinical data of 232 patients with MDR-TB admitted to Affiliated Hospital of Zunyi Mdeical University from June 2022 to June 2024 were se-lected.According to the treatment outcome,they were divided into the good group and the poor group.The clini-cal characteristics and related influencing factors based on the Hatton model were analyzed.Results Among 232 patients with MDR-TB,54 patients had adverse outcomes,accounting for 23.28％.Based on the Hatton model framework,a multivariate Logistic regression analysis was conducted.The results showed that the host factor(before the event:BMI＜18.5 kg/m2;Vector factors(during the event:Adverse drug reactions,sputum cul-ture not turning negative at the end of the 6th month,presence of cavities before treatment,and no improvement in cavity closure at the 6th month);and Environmental factors(in the event:Lack of long-term supervision and management and irregular medication use)are risk factors for adverse treatment outcomes in patients with MDR-TB(P＜0.05).Conclusion The adverse treatment outcome of MDR-TB is the result of the combined effects of host factors(low BMI),vector factors(adverse drug reactions,sputum bacteria not turning negative during treatment and cavity not improving),and environmental factors(lack of supervision and management,irregular medication)in the pre-treatment and mid-treatment stages.Targeted intervention measures can be formulated to reduce the risk of adverse outcomes.关键词
耐多药肺结核/哈顿模型/治疗转归/临床特征/影响因素Key words
multidrug-resistant tuberculosis/Hatton model/treatment outcome/clinical features/influencing factor分类
医药卫生引用本文复制引用
吴小艳,郑巧,王杭,李娜娜..基于哈顿模型的耐多药肺结核不良治疗转归的临床特征及影响因素分析[J].遵义医科大学学报,2025,48(9):938-944,952,8.基金项目
贵州省科技厅基础研究计划项目[NO:黔科合基础-ZK(2022)一般648]. （2022）
