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Essential role of the metabolite α-ketoglutarate in bone tissue and bone-related diseases

Zuping Wu Yuzhe Guan Qian Chen Ruifeng Song Jing Xie Xin Zhang Yan Wang Qianming Chen Xiaoyan Chen

Acta Biochimica et Biophysica Sinica2025，Vol.57Issue(8)：P.1207-1221,15.

Acta Biochimica et Biophysica Sinica2025，Vol.57Issue(8)：P.1207-1221,15.DOI:10.3724/abbs.2025020

Essential role of the metabolite α-ketoglutarate in bone tissue and bone-related diseases

Zuping Wu ¹Yuzhe Guan ¹Qian Chen ¹Ruifeng Song ¹Jing Xie ²Xin Zhang ³Yan Wang ⁴Qianming Chen ¹Xiaoyan Chen¹

作者信息

1. Stomatology Hospital,School of Stomatology,Zhejiang University School of Medicine,Zhejiang Provincial Clinical Research Center for Oral Diseases,Key Laboratory of Oral Biomedical Research of Zhejiang Province,Cancer Center of Zhejiang University,Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province,Hangzhou 310000,China
2. State Key Laboratory of Oral Diseases,West China Hospital of Stomatology,Sichuan University,Chengdu 610064,China
3. Shandong University&Shandong Key Laboratory of Oral Tissue Regeneration&Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration&Shandong Provincial Clinical Research Center for Oral Diseases,Jinan 250000,China
4. ShengSi County People’s Hospital,Zhoushan 316000,China
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摘要

关键词

α-ketoglutarate/bone metabolism/osteoporosis/osteoarthritis/rheumatoid arthritis/periodontitis

分类

医药卫生

引用本文复制引用

Zuping Wu,Yuzhe Guan,Qian Chen,Ruifeng Song,Jing Xie,Xin Zhang,Yan Wang,Qianming Chen,Xiaoyan Chen..Essential role of the metabolite α-ketoglutarate in bone tissue and bone-related diseases[J].Acta Biochimica et Biophysica Sinica,2025,57(8):P.1207-1221,15.

基金项目

supported by the grants from the National Natural Science Foundation of China(No.82271008 to X.C.and No.82330029 to Q.C.) （No.82271008 to X.C.and No.82330029 to Q.C.）

the Key R&D Program of Zhejiang Province(No.2024C03193 to Q.C.) （No.2024C03193 to Q.C.）

the Zhejiang Provincial Natural Science Foundation of China(No.LQ24H140004 to Z.W.). （No.LQ24H140004 to Z.W.）

Acta Biochimica et Biophysica Sinica

ISSN：1672-9145

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