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Development of berberine derivative-loaded nanovesicles for ROS-driven eradication of Helicobacter pylori:Overcoming antibiotic resistance and disruption of gut microbiota

Yuanyuan Li Suqi Hao Yuhan Fan Jiabao Hao Aojie Li Yalong Wang Haiyan Hu Shijie Ma Shihui Yu

Nano Research2025，Vol.18Issue(8)：P.797-811,15.

Nano Research2025，Vol.18Issue(8)：P.797-811,15.DOI:10.26599/NR.2025.94907674

Development of berberine derivative-loaded nanovesicles for ROS-driven eradication of Helicobacter pylori:Overcoming antibiotic resistance and disruption of gut microbiota

Yuanyuan Li ¹Suqi Hao ¹Yuhan Fan ¹Jiabao Hao ¹Aojie Li ¹Yalong Wang ¹Haiyan Hu ²Shijie Ma ¹Shihui Yu¹

作者信息

1. School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,China
2. School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,China State Key Laboratory of Anti-Infective Drug Discovery and Development,School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,China Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery,School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,China
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摘要

关键词

Helicobacter pylori(H.pylori)/bacterial resistance/intracellular bacterial persistence/gut microbiota/reactive oxygen species(ROS)-driven therapy

分类

医药卫生

引用本文复制引用

Yuanyuan Li,Suqi Hao,Yuhan Fan,Jiabao Hao,Aojie Li,Yalong Wang,Haiyan Hu,Shijie Ma,Shihui Yu..Development of berberine derivative-loaded nanovesicles for ROS-driven eradication of Helicobacter pylori:Overcoming antibiotic resistance and disruption of gut microbiota[J].Nano Research,2025,18(8):P.797-811,15.

基金项目

supported by the National Natural Science Foundation of China(No.82273870) （No.82273870）

Guangzhou Science and Technology key Program(No.2023B03J0022) （No.2023B03J0022）

Guangdong Basic and Applied Basic Research Foundation,China(Nos.2023A1515012909,2024A1515011193,and 2025A1515011086) （Nos.2023A1515012909,2024A1515011193,and 2025A1515011086）

Guangzhou Science and Technology Program(No.2025A04J4525) （No.2025A04J4525）

Guangdong Provincial Key Laboratory of Construction Foundation(No.2023B1212060022). （No.2023B1212060022）

Nano Research

ISSN：1998-0124

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