首页|期刊导航|Marine Life Science & Technology|A novel anti-OX40 human monoclonal antibody that blocks OX40/OX40L signaling and depletes OX40+T cells

A novel anti-OX40 human monoclonal antibody that blocks OX40/OX40L signaling and depletes OX40+T cells

Zhen Li Lin Liu Xiaobo Chen Yanqing Wang Yuxuan Wang Yuxiu Zhang Bingqiang Zhang Xiao Wu Muhammad Omer Iqbal Jin Chen Yuchao Gu

Marine Life Science & Technology2025，Vol.7Issue(2)：P.328-339,12.

Marine Life Science & Technology2025，Vol.7Issue(2)：P.328-339,12.DOI:10.1007/s42995-025-00284-y

A novel anti-OX40 human monoclonal antibody that blocks OX40/OX40L signaling and depletes OX40+T cells

Zhen Li ¹Lin Liu ¹Xiaobo Chen ²Yanqing Wang ³Yuxuan Wang ⁴Yuxiu Zhang ¹Bingqiang Zhang ⁵Xiao Wu ⁶Muhammad Omer Iqbal ⁷Jin Chen ⁸Yuchao Gu⁸

作者信息

1. School of Medicine and Pharmacy,Ocean University of China,Qingdao 266003,China Jingyuan Biosciences(Suzhou)Co Ltd,Suzhou 215000,China
2. Jingyuan Biosciences(Suzhou)Co Ltd,Suzhou 215000,China
3. School of Medicine and Pharmacy,Ocean University of China,Qingdao 266003,China Qingdao Center of Technology Innovation for Shark Antibody Development,College of Biological Engineering,Qingdao University of Science and Technology,Qingdao 266042,China
4. School of Medicine and Pharmacy,Ocean University of China,Qingdao 266003,China
5. Key Laboratory of Cancer and Immune Cells of Qingdao,Qingdao Restore Biotechnology Co Ltd,Qingdao 266111,China
6. Qingdao Central Hospital,University of Health and Rehabilitation Sciences,Qingdao 266042,China
7. Fatima Tu Zahara Department of Life Sciences,Muhammad Institute of Medical and Allied Sciences,Multan 60000,Pakistan
8. Qingdao Center of Technology Innovation for Shark Antibody Development,College of Biological Engineering,Qingdao University of Science and Technology,Qingdao 266042,China
折叠

摘要

关键词

Atopic dermatitis/OX40/Phage display/Fully human antibody/Computer simulation/Epitope scanning

分类

医药卫生

引用本文复制引用

Zhen Li,Lin Liu,Xiaobo Chen,Yanqing Wang,Yuxuan Wang,Yuxiu Zhang,Bingqiang Zhang,Xiao Wu,Muhammad Omer Iqbal,Jin Chen,Yuchao Gu..A novel anti-OX40 human monoclonal antibody that blocks OX40/OX40L signaling and depletes OX40+T cells[J].Marine Life Science & Technology,2025,7(2):P.328-339,12.

基金项目

funded by the Qingdao Marine Science and Technology Center(8-01 and No.20220NLM030003-4) （8-01 and No.20220NLM030003-4）

National Key Research and Develop-ment Program of China(2024YFA0918404 and 2022YFF0713100) （2024YFA0918404 and 2022YFF0713100）

the Taishan Scholars Program(No.tsqn202211058),and Jingyuan Biosciences(Suzhou)Co.,Ltd. （No.tsqn202211058）

Marine Life Science & Technology

ISSN：2096-6490

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