纺织科学与工程学报2025，Vol.42Issue(5)：59-64,6.DOI:10.3969/j.issn.2096-5184.2025.05.010
抗氧化抗菌纤维膜/水凝胶复合敷料的制备及性能研究
Preparation and Properties of Antioxidant and Antibacterial Fibrous Membrane/Hydrogel Composite Dressing
摘要
Abstract
Diabetic chronic wounds,characterized by excessive oxidative stress and a high susceptibility to bacterial infection,lead to delayed healing which significantly impacts patient health.There is an urgent need to develop functional wound dressings integrated with antioxidant and antibacterial properties.In this study,a fi-brous membrane/hydrogel bilayer dressing was developed.The lower layer consisted of hyaluronic acid hydrogels loaded with luteolin,providing antioxidant properties.The upper layer was polylactic acid electrospun fibrous membrane loaded with gold nanorod,which enabled physical antibacterial activity through near-infrared photo-thermal effects.Experimental results demonstrated that the hydrogel layer achieved a DPPH radical scavenging rate of 86.79%within 30 minutes,indicating significant antioxidant activity.Furthermore,under NIR irradiation(808 nm,2 W/cm2,5 min),the surface temperature of the dressing increased to 58.5℃,resulting in an anti-bactericidal rate of 99.88%against staphylococcus aureus.This research offered a new approach for developing antioxidant and antibacterial dressings.关键词
抗氧化/抗菌/纳米纤维膜/水凝胶/光热性能Key words
antioxidant/antibacterial/nanofibrous membrane/hydrogel/photothermal property分类
医药卫生引用本文复制引用
孟金梅,唐金红,李晓然..抗氧化抗菌纤维膜/水凝胶复合敷料的制备及性能研究[J].纺织科学与工程学报,2025,42(5):59-64,6.基金项目
中央高校基本科研业务费专项资金项目,东华大学励志计划(LZA2021001) （LZA2021001）
