结直肠肛门外科2025，Vol.31Issue(4)：332-337,6.DOI:10.19668/j.cnki.issn1674-0491.2025.04.008
基于倾向性评分匹配的消痔灵注射固脱法治疗完全性直肠脱垂的疗效评价
Efficacy evaluation of Xiaozhiling injections fixation-prolapse-reduction technique for com-plete rectal prolapse using propensity score matching
摘要
Abstract
Objectives To compare the efficacy of Xiaozhiling injections fixation-prolapse-reduction technique and non-injection therapy for complete rectal prolapse.Methods A retrospective analysis included 191 patients with complete rec-tal prolapse treated at Guang'anmen Hospital,China Academy of Chinese Medical Sciences between January 2002 and De-cember 2023.Patients were divided into an injection group(treated with Xiaozhiling injections fixation-prolapse-reduction technique,n=134)and a non-injection group(treated with other non-injection therapy,n=57).Propensity score match-ing using the nearest neighbor method was performed at a 2:1 ratio,resulting in matched groups:injection group(n=86)and non-injection group(n=43).Data collected and compared included:short-term efficacy indicators[clinical ef-ficacy at 1 month post-treatment,incidence of complications within 1 month post-treatment(rash,nausea,vomiting,in-testinal necrosis,fever,pelvic heaviness,diarrhea,constipation,urinary retention,cardiovascular events,incomplete intesti-nal obstruction)],long-term efficacy indicators(rectal prolapse recurrence),and other relevant indicators[hospital stay length,hospitalization costs,surgical trauma indicators(anesthesia method,operation time,intraoperative blood loss),and postoperative recovery indicators(postoperative hospital stay,postoperative symptom scores,fasting time,duration and number of antibiotics used)].Results The overall efficacy rate(97.7％vs.100％)and recurrence rate(39.5％vs.51.2％)were comparable between the injection group and the non-injection group(P＞0.05).The total incidence of com-plications within 1 month postoperatively was significantly lower in the injection group compared to the non-injection group(45.3％vs.93％,P＜0.05).The injection group had significantly shorter hospital stay,operation time,fasting time,and antibiotic duration,as well as less hospitalization costs and intraoperative blood loss(P＜0.05).The distribution of anesthesia methods differed significantly between the two groups(P＜0.05).No significant differences were found in postoperative hospital stay,postoperative symptom scores,or the number of antibiotics used(P＞0.05).Conclusion Both treatment approaches demonstrated comparable short-term and long-term efficacy.However,the Xiaozhiling injection fixation-prolapse-reduction technique was superior to non-injection therapy in reducing complication rates,minimizing sur-gical trauma,and accelerating postoperative recovery.关键词
直肠脱垂/消痔灵/注射固脱法/非注射疗法/倾向性评分匹配Key words
rectal prolapse/Xiaozhiling/injection fixation-prolapse-reduction technique/non-injection therapy/propensity score matching分类
医药卫生引用本文复制引用
崔国策,焦霞,张铢惠,李华山..基于倾向性评分匹配的消痔灵注射固脱法治疗完全性直肠脱垂的疗效评价[J].结直肠肛门外科,2025,31(4):332-337,6.基金项目
国家自然科学基金项目(81673988) （81673988）
