临床误诊误治2025，Vol.38Issue(19)：26-32,7.DOI:10.3969/j.issn.1002-3429.2025.19.005
动态监测淋巴细胞亚群联合白细胞介素-6变化对肺癌放疗患者肺部感染的预测效能
Predictive efficacy of dynamic monitoring of lymphocyte subsets combined with IL-6 changes for pulmonary infection in patients undergoing radiotherapy for lung cancer
摘要
Abstract
Objective To investigate the predictive efficacy of dynamic monitoring of lymphocyte subsets combined with interleukin-6(IL-6)changes for pulmonary infection in patients undergoing radiotherapy for lung cancer.Methods A cohort study was conducted on 115 lung cancer patients who underwent radiotherapy in our hospital from May 2018 to March 2021.They were divided into the infection group(n=26)and the uninfection group(n=89)based on the occurrence of pulmonary infection.The baseline data,as well as the C-reactive protein(CRP),white blood cell count(WBC),CD3+,CD4+/CD8+and IL-6 levels before and after radiotherapy were compared between the two groups.Pearson correlation analysis was used to analyze the relationship between lymphocyte subsets,IL-6 and CRP.The influencing factors of pulmonary infection after radiotherapy were analyzed by multivariate Logistic regression.The receiver operating characteristic(ROC)curve was used to analyze the value of lymphocyte subsets combined with IL-6 in predicting pulmonary infection.Results There was no significant difference in baseline data between the two groups(P>0.05).The CRP in the infection group after radiotherapy was higher than that before radiotherapy,and higher than that in the uninfection group(P<0.05).CD3+and CD4+/CD8+in the infection group were lower than those in the uninfection group before and after radiotherapy,and IL-6 was higher than that in the uninfection group(P<0.05).CD3+and CD4+/CD8+were negatively correlated with CRP,and IL-6 was positively correlated with CRP(P<0.01).CD3+,CD4+/CD8+and IL-6 before radiotherapy were all related influencing factors of pulmonary infection in patients with lung cancer undergoing radiotherapy(P<0.01).The area under the curve of CD3+,CD4+/CD8+combined with IL-6 before radiotherapy for predicting pulmonary infection in patients with lung cancer undergoing radiotherapy was the largest,which was 0.903.Conclusion CD3+,CD4+/CD8+and IL-6 are related to the occurrence of pulmonary infection in patients with lung cancer undergoing radiotherapy.Dynamic monitoring of the changes of the three indicators can provide effective reference information for clinical prediction of pulmonary infection in patients.关键词
肺肿瘤/淋巴细胞亚群/放疗/肺部感染/白细胞介素-6/C反应蛋白/影响因素/预测效能Key words
lung neoplasms/lymphocyte subsets/radiotherapy/pulmonary infection/interleukin-6/C-reactive protein/influencing factor/predictive efficacy引用本文复制引用
张惠杰,杨丹丹,陈丽颖,刘婧琳..动态监测淋巴细胞亚群联合白细胞介素-6变化对肺癌放疗患者肺部感染的预测效能[J].临床误诊误治,2025,38(19):26-32,7.基金项目
河北省医学科学重点研究课题计划项目(20201317) （20201317）
