临床误诊误治2025，Vol.38Issue(19)：132-140,9.DOI:10.3969/j.issn.1002-3429.2025.19.020
核因子-κB信号通路在急慢性肾损伤肾纤维化中的研究进展
Research progress of NF-κB signaling pathway in renal fibrosis caused by acute and chronic renal injury
摘要
Abstract
Renal fibrosis is the core pathological feature of the progression from acute kidney injury(AKI)to chronic kidney disease(CKD),with a complex mechanism and extremely poor prognosis.The activation of nuclear factor-κB signaling pathway is closely related to the transition from AKI to CKD.It is not only an important regulator of inflammatory reaction,but also affects the renal fibrosis process through interaction with various signaling pathways and epigenetic regulation;however,its specific mechanism is still unclear.Therefore,this article summarizes the mechanism of nuclear factor-κB signaling pathway in renal fibrosis in the progression from AKI to CKD,and the research progress of various intervention strategies,in order to provide theoretical basis and new direction for targeting nuclear factor-κB pathway to prevent and treat renal fibrosis.关键词
急性肾损伤/慢性肾脏病/肾纤维化/核因子-κB信号通路/干预策略/病理特征/表观遗传/综述Key words
acute renal injury/chronic kidney disease/renal fibrosis/nuclear factor-κB signal pathway/intervention strategy/pathological feature/epigenetics/review引用本文复制引用
方春天,李甜,伍杨,万立平,席春生..核因子-κB信号通路在急慢性肾损伤肾纤维化中的研究进展[J].临床误诊误治,2025,38(19):132-140,9.基金项目
甘肃省卫生健康行业科研计划项目(GSWSKY2022-51) （GSWSKY2022-51）
兰州市科技计划项目(2023-ZD-173) （2023-ZD-173）
联勤保障部队第九四〇医院专项课题(2022yxky017) （2022yxky017）
