内蒙古民族大学学报（自然科学版）2025，Vol.40Issue(5)：9-14,6.DOI:10.14045/j.cnki.15-1220.2025.05.002
蒙药手参延缓衰老功效实验研究
Experimental Study on the Anti-Aging Effect of Mongolian Medicine Gymnadenia Conopsea
摘要
Abstract
Gymnadenia conopsea,a distinctive medicinal herb in Mongolian medicine,exhibits remarkable anti-aging effects.This study investigated the anti-aging mechanism of Gymnadenia conopsea by establishing a D-galactose-induced aging model in ICR mice.The experimental design included a normal control group,a model group,a vitamin E group,and high,medium,and low dose Gymnadenia conopsea groups(2.4,1.2 and 0.6 g/kg,respectively).After four weeks of administration,compared with the model group,all Gymnadenia conopsea dose groups showed significantly improvement of spatial learning and memory abilities in mice(P＜0.05 or P＜0.01),increase of liver,kidney,and spleen indices,enhancement of total antioxidant capacity(T-AOC)and superoxide dismutase(SOD)activities in brain tissue,liver tissue and serum(P＜0.05 or P＜0.01),and decrease of malondialdehyde(MDA)and lipid peroxides(LIPO)contents in serum and tissues(P＜0.05 or P＜0.01).Among them,the T-AOC and SOD activities in all Gymnadenia conopsea dose groups were significantly higher than those in the model group,the MDA content was significantly lower than that in the model group,and the high-dose group(2.4 g/kg)was close to the vitamin E group in terms of the increase of T-AOC activity.The study demonstrates that Gymnadenia conopsea exerts its anti-aging effects by enhancing antioxidant enzyme activity,reducing lipid peroxidation products,and effectively scavenging free radicals.These findings provide experimental support for elucidating the anti-aging mechanism of Mongolian medicine Gymnadenia conopsea.关键词
手参/抗衰老/记忆能力Key words
Gymnadenia conopsea/anti-aging/memory ability分类
医药卫生引用本文复制引用
斯琴,孟和毕力格,斯琴格日乐,包晓华..蒙药手参延缓衰老功效实验研究[J].内蒙古民族大学学报（自然科学版）,2025,40(5):9-14,6.基金项目
内蒙古自治区自然科学基金项目(2017MS0887) （2017MS0887）
重点提升为国家级重点实验室平台能力建设项目(NMKJZX1702) （NMKJZX1702）
内蒙古民族大学博士科研启动基金项目(BS387) （BS387）
