山东医药2025，Vol.65Issue(9)：29-34,6.DOI:10.3969/j.issn.1002-266X.2025.09.007
七叶皂苷钠对骨科术后下肢静脉血栓防治效果的系统评价
Preventive and therapeutic effects of sodium aescinate on lower extremity venous thrombosis after orthopedic surgery:a Meta-analysis
摘要
Abstract
Objective To systematically evaluate the clinical efficacy of sodium aescinate in the prevention and treatment of lower extremity venous thrombosis following orthopedic surgery.Methods A comprehensive search was con-ducted in both English and Chinese databases,including PubMed,Embase,Cochrane Library,CNKI,Wanfang,and VIP,from database inception to April 2025.The search terms used were"sodium aescinate","venous thrombosis",and"orthopedic surgery".Relevant literature was selected after applying inclusion and exclusion criteria and We evaluated the studies using the Cochrane Handbook for Systematic Reviews and the Newcastle-Ottawa Scale(NOS).Outcome indicators included the incidence of venous thrombosis,C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),D-dimer,activated partial thromboplastin time(APTT),prothrombin time(PT),fibrinogen(FIB),whole blood high shear viscosity,whole blood low shear viscosity,plasma viscosity,and adverse event rates.Results A total of 21 studies,involving 2,324 patients,were included,with 1,221 patients in the sodium aescinate group and 1,103 in the control group.The incidence of venous thrombosis was significantly lower in the sodium aescinate group than in the con-trol group(RR=0.51,95%CI:0.41-0.64,P<0.05).Significant differences were found in serum IL-6(SMD=-1.90,95%CI:-2.82--0.98),TNF-α(SMD=-1.00,95%CI:-1.33--0.67),D-dimer(SMD=-1.35,95%CI:-2.29--0.42),APTT(SMD=5.37,95%CI:1.74-9.00),whole blood high shear viscosity(mPa•s)(SMD=-2.50,95%CI:-3.65--1.35),plasma viscosity(mPa•s)(SMD=-1.57,95%CI:-2.40--0.74),whole blood high shear viscosity(at shear rate of 150/s)(SMD=2.37,95%CI:0.48-4.26),whole blood low shear viscosity(at shear rate of 10/s)(SMD=2.99,95%CI:1.31-4.66),and plasma viscosity(at shear rate of 120/s)(SMD=2.32,95%CI:2.00-2.64)between these two groups(all P<0.05).No significant differences were found in CRP(SMD=-0.83,95%CI:-1.94-0.28),PT(SMD=0.72,95%CI:-0.36-1.79),FIB(SMD=-0.55,95%CI:-1.66-0.57),whole blood low shear viscosity(SMD=-1.46,95%CI:-3.49-0.56)or adverse event rates between these two groups(all P>0.05).Conclusion Sodium aescinate is effective in preventing and treating lower extremity venous thrombosis after orthopedic surgery,with a favor-able safety profile.关键词
七叶皂苷钠/静脉血栓/下肢静脉血栓/炎症因子/凝血功能Key words
sodium aescinate/venous thrombosis/lower extremity venous thrombosis/inflammatory cytokines/coagulation function分类
医药卫生引用本文复制引用
马彤彤,王娜,田庆杰,刘英杰,郑军,王宏伟,蒋雨宸,李旻..七叶皂苷钠对骨科术后下肢静脉血栓防治效果的系统评价[J].山东医药,2025,65(9):29-34,6.基金项目
河北省医学科学研究课题计划项目(20201241) （20201241）
河北省政府资助临床医学优秀人才培养项目(ZF2024200). （ZF2024200）
