山东医药2025，Vol.65Issue(9)：51-55,5.DOI:10.3969/j.issn.1002-266X.2025.09.011
循环抗氧化剂与脓毒症不同亚型因果关系的双样本孟德尔随机化分析
Causal relationships between circulating antioxidants and different subtypes of sepsis:a two-sample Mendelian randomization study
摘要
Abstract
Objective To investigate the causal relationships between circulating antioxidants and different sub-types of sepsis using Mendelian randomization(MR)analysis,and to assess the impact of antioxidant levels on susceptibil-ity and prognosis of different subtypes of sepsis.Methods Based on genome-wide association study(GWAS)data,a bi-directional two-sample MR analysis was conducted to evaluate the effects of circulating antioxidants(α-tocopherol,γ-to-copherol,ascorbic acid,retinol,β-carotene,and lycopene)on the risk of distinct sepsis subtypes(streptococcal sepsis and postpartum sepsis)and 28-day mortality.Circulating antioxidants significantly associated with sepsis in GWAS data were selected as instrumental variables.The primary analytical method was inverse variance weighting(IVW),with weighted median and MR-Egger regression applied for robustness testing.Pleiotropy and heterogeneity analyses were per-formed to evaluate the reliability of the results.Results IVW analysis revealed a significant association between the blood circulating γ-tocopherol metabolite level and susceptibility to postpartum sepsis(OR=0.620,95%CI:0.402-0.956,P<0.05),supplementary analyses yielded consistent results in direction,indicating robustness.Scatter plots sug-gested a negative causal effect of γ-tocopherol levels on postpartum sepsis.Leave-one-out analysis indicated no single SNP driving the association.Cochran's Q test suggested no heterogeneity,and pleiotropy tests detected no directional pleiotro-py.Conclusions The γ-tocopherol,among circulating antioxidants,may have a causal relationship with postpartum sep-sis.Higher γ-tocopherol levels may help reduce the risk of postpartum sepsis.In contrast,for other sepsis subtypes,there is no robust evidence to support a reduction in incidence.关键词
循环抗氧化剂/脓毒症/孟德尔随机化/γ-生育酚Key words
circulating antioxidants/sepsis/Mendelian randomization/γ-tocopherol分类
医药卫生引用本文复制引用
王敬杰,徐婧楠,于湘友,王毅..循环抗氧化剂与脓毒症不同亚型因果关系的双样本孟德尔随机化分析[J].山东医药,2025,65(9):51-55,5.基金项目
国家重点研发计划(2021YFC2500800) （2021YFC2500800）
新疆维吾尔自治区自然科学基金项目(2022D01C477) （2022D01C477）
新疆围手术期器官保护重点实验室自主开放课题(XJDX1411-2025-MZZ1). （XJDX1411-2025-MZZ1）
