山东医药2025，Vol.65Issue(9)：66-69,75,5.DOI:10.3969/j.issn.1002-266X.2025.09.014
常规实验室检查指标在川崎病早期诊断中的应用价值分析
Value of routine laboratory test indicators in the early diagnosis of children with Kawasaki disease
摘要
Abstract
Objective To explore the value of routine laboratory test indicators in the early diagnosis of Kawasaki disease.Methods A total of 280 children with Kawasaki disease were enrolled in the study group,and 104 feverish children without Kawasaki disease were included in the control group.Data including gender,age,disease course,and length of hospital stay were collected from both groups,along with data of blood routine indicators,blood biochemical in-dicators,and C-reactive protein(CRP)tests.Univariate analysis and multivariate Logistic regression analysis were used to identify the influencing factors of Kawasaki disease.Receiver operating characteristic(ROC)curves were plotted to evaluate the diagnostic efficacy of blood routine indicators,CRP,and blood biochemical indicators for Kawasaki disease.Results Compared with the control group,the study group had higher levels of neutrophil count,white blood cell count,alanine aminotransferase,total bilirubin,CRP,serum creatinine,lactate dehydrogenase,total bile acid,and platelets,while lower levels of prealbumin,blood chlorine,blood potassium,and blood sodium(all P<0.05).Taking the confirma-tion of Kawasaki disease as the dependent variable and the indicators with statistically significant differences in univariate analysis as independent variables,Logistic regression analysis showed that platelets,serum creatinine,total bile acid,and blood sodium were independent influencing factors for Kawasaki disease(all P<0.05).ROC curve analysis results re-vealed that the combined detection of platelets,serum creatinine,total bile acid,and blood sodium for diagnosing Kawasa-ki disease had a sensitivity of 0.90,a specificity of 0.99,and an area under the ROC curve(AUC)of 0.985(95%CI:0.967-0.995),which was higher than that of the individual detection of each indicator.Conclusions Among common laboratory test indicators,platelets,serum creatinine,total bile acid,and blood sodium are independent influencing fac-tors for Kawasaki disease.Children with abnormal levels of these indicators should be considered for the possibility of Ka-wasaki disease.The combined detection of platelets,serum creatinine,total bile acid,and blood sodium has high efficacy in diagnosing Kawasaki disease.关键词
川崎病/血常规指标/血生化指标/C反应蛋白/血小板/肌酐/总胆汁酸/血钠Key words
Kawasaki disease/blood routine indicators/blood biochemical indicators/C-reactive protein/plate-lets/creatinine/total bile acid/blood sodium分类
医药卫生引用本文复制引用
邓斌,何永,杨紫薇,康迁,黄越,刘崇海..常规实验室检查指标在川崎病早期诊断中的应用价值分析[J].山东医药,2025,65(9):66-69,75,5.基金项目
川北医学院校级科研发展计划项目(CBY21-QA45). （CBY21-QA45）
