四川大学学报（自然科学版）2025，Vol.62Issue(5)：1224-1233,10.DOI:10.19907/j.0490-6756.250013
RNA-蛋白质相分离凝聚过程中RNA的调节模型研究
Study of regulatory models of RNA in RNA-protein phase separation condensation
摘要
Abstract
This modeling study aims to model the regulatory role of RNA in RNA-protein(PROT)phase separation condensation(PSC).First,based on diffusion kinetics and Hill kinetics,a novel theoretical model for dynamic RNA-PROT PSC is proposed.Second,molecular dynamics simulations were utilized to elucidate the regulatory mechanisms of physical affinity and bonding interactions within RNA-PROT multiva-lent interactions in modulating RNA-PROT PSC.The findings demonstrate that multivalent interactions be-tween RNA and PROT induce multiphase separation within the RNA-PROT interaction system,leading to the formation of RNA-PROT condensates.RNA regulates RNA-PROT PSC through multivalent interac-tions,which is a synergistic outcome of physical affinity and bonding reactions between RNA and PROT.These results not only reveal the physical nature of dissipation and free-energy regulation in RNA-PROT PSC but also provide a more precise understanding of RNA's regulatory effects on RNA-PROT PSC via multivalent interactions with PROT.关键词
非平衡态统计物理/RNA-蛋白质(PROT)相分离凝聚/扩散动力学/分子动力学模拟Key words
Nonequilibrium statistical physics/RNA-protein(PROT)phase separation condensation/Diffu-sion dynamics/Molecular dynamics simulation分类
生物科学引用本文复制引用
韩托弟,郭秀珍,赵新军,党玉洁..RNA-蛋白质相分离凝聚过程中RNA的调节模型研究[J].四川大学学报（自然科学版）,2025,62(5):1224-1233,10.基金项目
国家自然科学基金(22163011) （22163011）
2025年度新疆凝聚态相变与微结构实验室开放课题(JY2025) （JY2025）
