实用医学杂志2025，Vol.41Issue(19)：2961-2966,6.DOI:10.3969/j.issn.1006-5725.2025.19.001
基于肿瘤异质性的转移性结直肠癌患者基因检测专家共识(2025版)
Expert consensus on genetic testing for metastatic colorectal cancer patients based on tumor heterogeneity
广东省抗癌协会肿瘤多学科诊疗(MDT)专委会1
作者信息
摘要
Abstract
Colorectal cancer is one of the most prevalent malignant tumors in China.Chemotherapy,targeted therapy,and immunotherapy constitute the primary treatment modalities for patients with metastatic colorectal cancer.With the advancement of precision medicine,next-generation gene sequencing has become an essential component of the diagnostic and therapeutic process for metastatic colorectal cancer.Gene sequencing results provide critical guidance for the formulation of individualized treatment strategies.However,colorectal cancer exhibits significant tumor heterogeneity.Within the same patient,genetic profiles may differ between primary and metastatic tumors,as well as between tumor tissues obtained before and after treatment.A comprehensive and accurate understanding of these genetic differences is crucial for optimizing treatment efficacy.To address this issue,the Multidisciplinary Diagnosis and Treatment Committee of the Guangdong Anti-Cancer Association convened a panel of domestic multidis-ciplinary experts to develop the Expert Consensus on Genetic Testing for Patients with Metastatic Colorectal Cancer Based on Tumor Heterogeneity(2025 Edition)following extensive discussions.This consensus aims to maximize patient treatment outcomes and enhance the overall standard of colorectal cancer diagnosis and management in China.关键词
结直肠癌/异质性/基因检测/专家共识Key words
colorectal cancer/heterogeneity/gene sequencing/expert consensus分类
医药卫生引用本文复制引用
广东省抗癌协会肿瘤多学科诊疗(MDT)专委会..基于肿瘤异质性的转移性结直肠癌患者基因检测专家共识(2025版)[J].实用医学杂志,2025,41(19):2961-2966,6.
