汕头大学医学院学报2025，Vol.38Issue(3)：129-134,6.DOI:10.13401/j.cnki.jsumc.2025.03.001
基于静息态功能磁共振成像的甲状腺相关性眼病脑自发活动及视觉网络连接研究
Brain spontaneous activity and visual network connectivity in thyroid-associated ophthalmopathy based on resting-state functional magnetic resonance imaging
蒲学佳 1吕涵青 2李主镜 2段柯 2王砚颖 2成官迅3
作者信息
- 1. 汕头大学医学院,广东 汕头 515041||深圳市中医院放射影像科,广东 深圳 518033
- 2. 深圳市中医院放射影像科,广东 深圳 518033
- 3. 汕头大学医学院,广东 汕头 515041||北京大学深圳医院医学影像科,广东 深圳 518036
- 折叠
摘要
Abstract
Objective:To investigate the characteristics of brain spontaneous activity and visual network connectivity patterns in thyroid-associated ophthalmopathy(TAO)patients with visual dysfunction using resting-state functional magnetic resonance imaging(rs-fMRI).Methods:In this case-control study,32 TAO patients with visual dysfunction and 22 healthy volunteers were recruited from Shenzhen Hospital of Traditional Chinese Medicine(September 2019-December 2024).Rs-fMRI data were acquired and preprocessed to generate amplitude of low-frequency fluctuation(ALFF)and fractional amplitude of low-frequency fluctuation(fALFF)maps for quantifying regional spontaneous brain activity.Regions exhibiting abnormal ALFF/fALFF values served as seeds for visual network functional connectivity(FC)analysis.Correlations between FC strength and clinical features were subsequently evaluated.Results:Compared to controls,the TAO group demonstrated:Significantly increased ALFF in the right parahippocampal gyrus and decreased ALFF in the left pericalcarine cortex(P<0.05);Reduced fALFF in the left pericalcarine cortex and left postcentral gyrus(both P<0.05);Weakened FC between the left pericalcarine cortex and right lingual gyrus,right middle frontal gyrus,and bilateral postcentral gyri,but enhanced FC with the left supplementary motor area and left fusiform gyrus(all P<0.05);Positive correlations of ALFF/fALFF values in aberrant regions with exophthalmos degree and extraocular muscle thickness(all P<0.05).Conclusion:TAO patients demonstrate abnormal spontaneous brain activity and visual network connectivity reorganization,providing neuroimaging evidence for the central neuropathological mechanisms of TAO.关键词
静息态功能磁共振成像/甲状腺相关性眼病/脑自发活动/功能连接/低频振幅/分数低频振幅Key words
resting-state functional magnetic resonance imaging/thyroid-associated ophthalmopathy/brain spontaneous activity/functional connectivity/amplitude of low-frequency fluctuation/fractional amplitude of low-frequency fluctuation分类
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蒲学佳,吕涵青,李主镜,段柯,王砚颖,成官迅..基于静息态功能磁共振成像的甲状腺相关性眼病脑自发活动及视觉网络连接研究[J].汕头大学医学院学报,2025,38(3):129-134,6.
