山西中医药大学学报2025，Vol.26Issue(8)：878-888,11.DOI:10.19763/j.cnki.2096-7403.2025.08.09
基于数据挖掘和网络药理学探讨国医大师朱良春治疗痛风的用药规律及作用机制
Exploration of medication patterns and mechanisms for gout treatment by Master Zhu Liangchun through data mining and network pharmacology
摘要
Abstract
Objective:To summarize medication patterns and explore mechanisms of National Master of Chinese Medi-cine Zhu Liangchun's gout treatments based on Gout(Turbid Stasis Impediment)Diagnosis,Treatment and Rehabilitation Manual.Methods:Medical records were analyzed to determine herb frequencies,properties,flavors,and meridian tro-pism;core herb combinations were identified through association rule mining and hierarchical clustering;network pharma-cology and molecular docking techniques elucidated therapeutic mechanisms.Results:92 prescriptions containing 227 herbs revealed herbs predominantly exhibiting neutral,warm,or cold properties;sweet,bitter,or pungent flavors;and liver,spleen,or stomach meridian tropism.Core combination:Tufuling,Weilingxian,Zexie,Yiyiren,Bixie.TCMSP identified 105 active components targeting 190 herb targets,intersecting with 100 of 2,321 gout targets from GeneCards/OMIM/Drug-Bank.PPI networks identified 10 core targets:TNF,IL-6,MMP-9,Akt1,BCL2,IL-1β,PTGS2,IFNγ,CXCL8,CCL2,GO/KEGG enrichment indicated regulation via PI3K-Akt and NF-kB pathways,linked to lipid metabolism,athero-sclerosis,and diabetic complications.Molecular docking confirmed stable binding between quercetin/kaempferol/naringenin and TNF/IL-6/MMP-9.Conclusion:Professor Zhu treated gout primarily through heat-clearing,wind-damp dispelling,impediment-dredging,diuresis-promoting,and stasis-transforming methods;core components(e.g.,quercetin,stigmas-terol,β-sitosterol)modulate TNF/Akt/IL-6 targets via PI3K-Akt and NF-κB pathways.关键词
痛风/浊瘀痹/中医药治疗/朱良春/临床经验/数据挖掘/网络药理学Key words
gout/turbid stasis impediment/traditional Chinese medicine therapy/Zhu Liangchun/clinical experi-ence/data mining/network pharmacology分类
医药卫生引用本文复制引用
刘慧,吴湘湘,王艳珠,黄昀烁,谢璇,赵金阁,郑春松..基于数据挖掘和网络药理学探讨国医大师朱良春治疗痛风的用药规律及作用机制[J].山西中医药大学学报,2025,26(8):878-888,11.基金项目
陈可冀中西医结合发展基金项目(CKJ2023002) （CKJ2023002）
