汕头大学医学院学报2025，Vol.38Issue(3)：148-152,158,6.DOI:10.13401/j.cnki.jsumc.2025.03.005
术前全身炎症反应指数对根治性结肠癌患者预后的预测价值
Predictive value of preoperative systemic inflammation response index for prognosis in patients with radical colon cancer
吴国 1汪丹凤 2林黛英 2林赟 2谢玉莲 2肖健宁2
作者信息
- 1. 汕头大学医学院,广东 汕头 515041||汕头市中心医院放射科,广东 汕头 515041
- 2. 汕头市中心医院放射科,广东 汕头 515041
- 折叠
摘要
Abstract
Objective:To investigate the predictive value of the preoperative systemic inflammation response index(SIRI)for disease-free survival(DFS)in patients undergoing radical colon cancer surgery.Methods:Clinical data of 284 patients who underwent radical surgery at Shantou Central Hospital from January 2014 to January 2019 were retrospectively analyzed.Inflammatory markers including neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),monocyte-to-lymphocyte ratio(MLR),systemic immune-inflammation index(SII),and SIRI were calculated from preoperative blood tests.The optimal cut-off values for predicting 5-year DFS were determined using time-dependent receiver operating characteristic(ROC)curves.Patients were divided into high and low SIRI groups based on the optimal cut-off value.Survival curves were plotted using the Kaplan-Meier method and compared with the log-rank test.Prognostic factors were analyzed using Cox proportional hazards regression models.Results:A total of 284 patients were included,comprising 161 males(56.7%)and 123 females(43.3%),with a mean age of 62±13 years.SIRI demonstrated superior predictive efficacy for DFS(AUC=0.813)compared to NLR,PLR,MLR,and SII.The median follow-up time was 80.7 months.Survival analysis revealed that the high SIRI group had significantly shorter DFS than the low SIRI group(P<0.001).Multivariate Cox analysis identified preoperative high SIRI(HR=1.732,95%CI:1.496-2.706,P<0.001),poor/moderate differentiation(HR=2.110,95%CI:1.503-3.189,P=0.020),T3-T4 stage(HR=1.620,95%CI:1.228-2.552,P=0.038),and N1-N2 stage(HR=1.448,95%CI:1.122-3.167,P=0.040)as independent risk factors for DFS.Conclusion:Preoperative SIRI is an effective predictive indicator for prognosis in patients with radical colon cancer,with superior predictive performance compared to conventional inflammatory markers.关键词
全身炎症反应指数/结肠癌/预后/无病生存期Key words
systemic inflammation response index/colon cancer/prognosis/disease-free survival分类
医药卫生引用本文复制引用
吴国,汪丹凤,林黛英,林赟,谢玉莲,肖健宁..术前全身炎症反应指数对根治性结肠癌患者预后的预测价值[J].汕头大学医学院学报,2025,38(3):148-152,158,6.
