实用中医内科杂志2025，Vol.39Issue(7)：32-36,后插6-后插7,7.DOI:10.13729/j.issn.1671-7813.Z20240919011
基于"阳微"理论探讨游离三碘甲状腺原氨酸与慢性心力衰竭的相关性:一项两样本孟德尔随机化研究
Exploring Correlation between Free Triiodothyronine and Chronic Heart Failure Based on Theory of"Weak Yang":A Two-Sample Mendelian Randomization Study
摘要
Abstract
Objective To explore the potential correlation between free triiodothyronine(FT3)and chronic heart failure(CHF)based on the theory of"weak Yang".Methods Using the two-sample Mendelian randomization method,the publicly available ge-nome-wide data was subjected to an association analysis study to analyze the relationship between FT3 and CHF.The Inverse Variance Weighted(IVW)method,MR-Egger method,weighted mode method,weighted median method and Simple mode meth-od were used for analysis,along with tests for heterogeneity,pleiotropy and sensitivity.Results The IVW method showed that FT3 was a risk factor for CHF(OR:1.214,95％CI:1.082～1.362,P＜0.001),indicating a positive causal relationship between FT3 and CHF.However,no causal relationship was found in the reverse MR.Conclusion The level of FT3 is positively correlated with the occurrence of CHF,providing new insights into the diagnosis and prediction of CHF.Additionally,FT3 has the potential to serve as an important factor in confirming the traditional Chinese medicine(TCM)theory of"weak Yang",offering theoretical support for the TCM etiology and pathogenesis ideas.关键词
孟德尔随机化/游离三碘甲状腺原氨酸/慢性心力衰竭/病因病机Key words
mendelian randomization/free triiodothyronine/chronic heart failure/etiology and pathogenesis分类
医药卫生引用本文复制引用
孙瑞鸽,段盈竹,张颖,梁健,于睿..基于"阳微"理论探讨游离三碘甲状腺原氨酸与慢性心力衰竭的相关性:一项两样本孟德尔随机化研究[J].实用中医内科杂志,2025,39(7):32-36,后插6-后插7,7.基金项目
国家中医药管理局科研基金项目(GZY-KJS-2020-026) （GZY-KJS-2020-026）
