畜牧兽医学报2025，Vol.56Issue(9)：4215-4231,17.DOI:10.11843/j.issn.0366-6964.2025.09.008
畜禽m6A甲基化修饰及营养调控研究进展
Advances in m6A Methylation Modification and Nutritional Regulation in Livestock and Poultry
摘要
Abstract
N6-methyladenosine(m6A)methylation represents a dynamic and reversible post-transcriptional modification regulated by m6A methyltransferases,m6A demethylases,and m6A reader proteins.It is recognized as the most prevalent RNA modification in eukaryotic organisms.Recent studies have progressively elucidated the biological roles of m6A methylation in livestock and poultry production,highlighting its involvement in regulating critical life processes,including growth and development,reproductive physiology,glucose and lipid metabolism,oxidative stress,and cellular damage.Alterations in factors such as nutrition,environment,and disease within livestock and poultry production can disrupt m6A methylation modifications,thereby impacting the physiological metabolic processes of these animals.Nonetheless,nutritional regulation strategies have the potential to restore methylation homeostasis,thereby facilitating the regulation of growth,development,and diseases in livestock and poultry.This article provides a comprehensive review of these topics,offering novel insights and strategies for enhancing growth performance and ensuring the health of livestock and poultry.关键词
m6A甲基化修饰/甲基化稳态/营养调控/畜禽Key words
m6A methylation modification/methylation homeostasis/nutrients regulation/livestock and poultry分类
农业科技引用本文复制引用
白广栋,楼泽楷,王瑞琪,赵轩,李家维,夏耀耀,庞家满..畜禽m6A甲基化修饰及营养调控研究进展[J].畜牧兽医学报,2025,56(9):4215-4231,17.基金项目
西南大学中央高校基础业务费(SWU-KR24022) （SWU-KR24022）
重庆市自然基金面上项目(CSTB2023NSCQ-MSX0621) （CSTB2023NSCQ-MSX0621）
