畜牧兽医学报2025，Vol.56Issue(9)：4241-4252,12.DOI:10.11843/j.issn.0366-6964.2025.09.010
冠状病毒S蛋白的结构和功能研究进展
Structure and Function of Coronavirus S Proteins
摘要
Abstract
The coronavirus(CoV)is a single-stranded positive-sense RNA virus with a lipid envelope,which is an important pathogenic agent of humans and animals.CoV infections mainly cause acute or chronic symptoms of respiratory system,liver,stomach and intestines,and nervous system of host.CoV mainly infects humans and a variety of animals,seriously endangering human health and the development of animal husbandry.Most of the spike(S)protein of CoV is composed of the S1 and S2 subunits,which are responsible for receptor binding and membrane fusion during the virus's infection of cells,respectively.It plays an important role in the virus's tissue or host tropism and virulence,and is a key protein for CoV to infect cells.This review focuses on the structure and function of the S protein of CoV,with the aim of providing a reference for exploring the invasion mechanism of CoV.关键词
冠状病毒/S蛋白/结构/功能Key words
coronaviruses/spike protein/structure/function分类
农业科技引用本文复制引用
黎梦帆,李青阳,宋艳雯,宋振辉,张兴翠..冠状病毒S蛋白的结构和功能研究进展[J].畜牧兽医学报,2025,56(9):4241-4252,12.基金项目
中央高校基本科研业务基金资助项目(SWU-KQ24032) （SWU-KQ24032）
