畜牧兽医学报2025，Vol.56Issue(9)：4294-4302,9.DOI:10.11843/j.issn.0366-6964.2025.09.014
动物源宿主防御肽抗微生物作用机制研究进展
Research Progress on the Mechanism of Host Defense Peptides against Microorganisms
摘要
Abstract
Host defense peptides(HDPs),as antimicrobial peptides(AMPs),are an important component of innate immunity and can protect the host against pathogens invasion.HDPs have broad-spectrum antimicrobial activity and are less susceptible to the production to drug resistance,which are potential candidates for the development of new anti-infectives.The antibacterial mechanism of action of HDPs is complicated,which not only acts on cell wall and membrane,but also affects the synthesis of nucleic acid,protein and metabolism.This article reviews the mechanism of action of HDPs on pathogens including bacteria,fungi,viruses,and parasites,which provides reference for the application of HDPs.关键词
宿主防御肽/微生物/作用机制Key words
host defense peptides/microorganisms/the mechanism of action分类
农业科技引用本文复制引用
潘言迪,张婷婷,方仁东,彭练慈..动物源宿主防御肽抗微生物作用机制研究进展[J].畜牧兽医学报,2025,56(9):4294-4302,9.基金项目
国家自然科学基金项目(32473043) （32473043）
中央高校基本科研业务费专项资金资助(SWU-KT25016) （SWU-KT25016）
国家生猪技术创新中心项目(NCTIP-XD/C17) （NCTIP-XD/C17）
重庆市生猪产业技术体系(CQMAITS202312) （CQMAITS202312）
重庆市高校创新研究群体(CXQT20004) （CXQT20004）
重庆市技术创新与应用发展专项(CSTB2024TIAD-LDX0009) （CSTB2024TIAD-LDX0009）
