中国临床药理学与治疗学2025，Vol.30Issue(9)：1260-1271,12.DOI:10.12092/j.issn.1009-2501.2025.09.013
以lncRNA和miRNA为主在肝癌代谢重编程调控中的作用和机制
The role and mechanisms of lncRNA and miRNA in metabolic repro-gramming regulation in hepatocellular carcinoma
摘要
Abstract
Hepatocellular carcinoma(HCC)is a cancer with extremely high mortality and incidence rates.In recent years,with the development of multidisciplinary approaches,key characteristics of cancer have gradually been revealed.Studies have shown that dysregulated energy metabolism and metabolic reprogramming in tumor cells form the basis for tumor cell growth and are critical factors in shaping the tumor microenvironment,immune evasion,and drug resistance.Non-coding RNAs(ncRNAs),as important regulatory factors,play a crucial role in the metabolic reprogramming of HCC.This article focuses on summarizing the mech-anisms by which ncRNAs regulate metabolic repro-gramming in HCC and explores their applications in clinical diagnosis,treatment,and prognostic assess-ment,aiming to provide new perspectives for effec-tive HCC treatment and the development of novel drug targets.关键词
肝细胞癌/非编码RNA/代谢重编程/糖代谢/脂质代谢/氨基酸代谢Key words
hepatocellular carcinoma/non-cod-ing RNAs/metabolic reprogramming/glucose me-tabolism/lipid metabolism/amino acid metabolism分类
医药卫生引用本文复制引用
蒋艳,宋沧桑,王国徽,毛盼盼,李兴德..以lncRNA和miRNA为主在肝癌代谢重编程调控中的作用和机制[J].中国临床药理学与治疗学,2025,30(9):1260-1271,12.基金项目
云南省科技厅科技计划(昆医联合专项,202301AY070001-112) （昆医联合专项,202301AY070001-112）
云南省临床药学中心建设项目(昆明市第一人民医院2022年-2025年) （昆明市第一人民医院2022年-2025年）
云南省科技厅重大科技专项计划项目(202302AA310018-F-6) （202302AA310018-F-6）
昆明市卫生科技人才培养项目(2022-SW(带头)-32) （2022-SW(带头）
云南省卫生健康委员会医学领军人才培养项目(L-2018012) （L-2018012）
