中国临床药理学与治疗学2025，Vol.30Issue(9)：1281-1289,9.DOI:10.12092/j.issn.1009-2501.2025.09.015
PARP抑制剂在脑胶质瘤治疗中的研究进展
Research progress of PARP inhibitors in the treatment of brain glioma
摘要
Abstract
Poly-(adenosine diphosphate-ribose)-polymerase(PARP)inhibitors are a novel group of small molecule targeted therapeutic drugs.It has become an effective treatment for ovarian cancer,prostate cancer and breast cancer carrying BRCA1/2 mutations.Studies have demonstrated that PARP inhibitors(PARPi)can improve treatment outcomes by targeting genetic defects in tumors with syner-gistic effects with standard therapies for glioma treatment,such as increasing radiation sensitivity and overcoming temozolomide resistance.Howev-er,the limited blood-brain barrier permeability,the adverse reactions of drug combination and the oc-currence of drug resistance are the key factors af-fecting the therapeutic effect.This article reviews the mechanism of action and research progress of PARP inhibitors involved in the treatment of brain glioma,and analyzes the challenges to be faced in clinical practice,in order to provide references for future research in this field.关键词
PARP抑制剂/脑胶质瘤/作用机制/血脑屏障透过率Key words
PARP inhibitors/brain glioma/mecha-nism of action/blood-brain barrier permeability分类
医药卫生引用本文复制引用
宋聪,高敬林,班峰,孟萌,王明霞..PARP抑制剂在脑胶质瘤治疗中的研究进展[J].中国临床药理学与治疗学,2025,30(9):1281-1289,9.基金项目
河北省自然基金重点项目资助(H2021206432) （H2021206432）
