中国临床药理学杂志2025，Vol.41Issue(16)：2263-2268,6.DOI:10.13699/j.cnki.1001-6821.2025.16.003
非奈利酮联合达格列净治疗老年糖尿病肾病患者的临床研究
Clinical trial of finerenone combined with dapagliflozin in treating elderly diabetic nephropathy patients
摘要
Abstract
Objective To observe the clinical efficacy and safety of finerenone tablets combined with dapagliflozin tablets in the treatment of elderly diabetic nephropathy(DN).Methods Elderly patients with DN in hospital were divided into treatment group and control group.The patients in control group were treated with oral dapagliflozin tablets once a day in the morning,with a dose of 5 mg each time,while the patients in the treatment group were combined with finerenone tablets on the basis of control group,and adjusted according to the estimated glomerular filtration rate(eGFR)levels of patients.Serum creatinine(SCr),blood urea nitrogen(BUN),24 h urine protein quantification,interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-cRP),total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)and clinical efficacy were compared between groups of patients,and the safety was evaluated.Results A total 90 patients were enrolced;45 in treatment group and 45 in control group.After treatment,the SCr levels in treatment group and control group were(127.63±10.28)and(140.27±11.95)μmol·L-1,BUN levels were(11.45±3.57)and(18.62±3.29)mmol·L-1,24 h urine protein quantification levels were(99.28±11.42)and(117.92±12.00)mg·24 h-1,IL-6 levels were(12.32±2.15)and(16.41±3.50)ng·L-1,TNF-α levels were(31.68±10.52)and(43.09±11.83)ng·L-1,hs-cRP levels were(6.08±1.20)and(9.56±1.57)ng·L-1,TC levels were(4.49±0.55)and(4.83±0.72)mmol·L-1,TG levels were(2.57±0.63)and(2.79±0.48)mmol·L-1,LDL-C levels were(2.71±0.63)and(3.06±0.45)mmol·L-1 respectively,and the above indicators in treatment group were significantly lower than those in control group,with statistically significant differences(all P＜0.05).The total clinical effective rate in treatment group was 93.34％(42 cases/45 cases),and that in control group was 75.56％(34 cases/45 cases),with statistically significant difference(P＜0.05).The adverse drug reactions in treatment group were hypotension,hypoglycemia,acute kidney injury,hyperkalemia and pruritus,and the adverse drug reactions in control group included hypoglycemia,acute kidney injury and hyperkalemia.The total incidence rates of adverse drug reactions in treatment group and control group were 22.22％(10 cases/45 cases)and 8.89％(4 cases/45 cases)respectively,without statistically significant difference(P＞0.05).Conclusion Compared with dapagliflozin tablets,the combined use of finerenone tablets for elderly DN can better improve the renal function,and regulate the lipid metabolism,with good safety.关键词
非奈利酮片/达格列净片/糖尿病肾病/脂质代谢/肾纤维化Key words
finerenone tablets/dapagliflozin tablets/diabetic nephropathy/lipid metabolism/renal fibrosis分类
医药卫生引用本文复制引用
胡淑阳,徐燕,徐梁..非奈利酮联合达格列净治疗老年糖尿病肾病患者的临床研究[J].中国临床药理学杂志,2025,41(16):2263-2268,6.基金项目
无锡市卫生健康委员会资助科研基金资助项目(Q202248) （Q202248）
