中国临床药理学杂志2025，Vol.41Issue(16)：2275-2280,6.DOI:10.13699/j.cnki.1001-6821.2025.16.005
夫西地酸软膏在非剥脱性点阵1565nm激光治疗的寻常痤疮患者中的临床研究
Clinical trial of fusidic acid ointment in patients with acne vulgaris treated with non-ablative fractional 1 565 nm laser
摘要
Abstract
Objective To explore the clinical efficacy of fusidic acid ointment in patients with acne vulgaris who underwent non-ablative fractional 1 565 nm laser treatment.Methods Patients with common acne who received non-peeling fractional 1 565 nm laser treatment were divided into treatment group and control group.Treatment group was treated with fusidic acid ointment,3 times a day,while control group was not treated with additional treatment.The lesion severity,skin sebum secretion,skin stratum corneum water content,clinical efficacy,matrix metalloproteinase 1(MMP-1),matrix metalloproteinase tissue inhibitor-1(TIMP-1),MMP-1/TIMP-1 ratio,skin elasticity indicators(R2,R5,R7),facial acne comprehensive grading system(global acne grading system,GAGS)score and acne-specific quality of life questionnaire(Acne-QOL)score were compared between the two groups.Results 100 patients with acne vulgaris who received non exfoliative dot matrix 1565 nm laser were enrolled,including 50 cases in treatment group and 50 cases in control group.After treatment,the total clinical effective rate of treatment group was 96.00％(48 cases/50 cases),and that of control group was 74.00％(37 cases/50 cases),the difference was statistically significant(P＜0.05).After 3 months treatment,the skin oil secretion of treatment group and control group were(53.79±7.23)and(69.21±10.67)μg·cm-2,respectively;the moisture content of cuticle were(34.21±5.15)％and(29.68±3.92)％,respectively;MMP-1 were(1.02±0.28)and(1.24±0.43)μg·mL-1,respectively;TIMP-1 were(1.62±0.24)and(1.43±0.20)μg·mL-1,respectively;MMP-1/TIMP-1 were 0.63±0.10 and 0.87±0.15,respectively;the R2 were(53.77±8.75)％and(49.11±7.64)％,respectively;the R5 were(53.88±8.58)％and(49.67±7.69)％,respectively;the R7 were(32.55±6.05)％and(28.39±5.44)％,respectively;the GAGS scores were(13.78±2.69)and(17.83±3.35)points,respectively;the Acne-QOL scores were(105.56±5.58)and(90.21±6.32)points,respectively.After treatment,the above indexes in treatment group were significantly lower than those in control group(all P＜0.05).The adverse drug reactions in treatment group and control group were dry,tingling,scaling and flushing.The total incidence of adverse drug reactions in treatment group was 10.00％(5 cases/50 cases)and in control group was 16.00％(8 cases/50 cases).There was no significant difference in the incidence of adverse drug reactions between the two groups(P＞0.05).Conclusion Fusidic acid ointment could significantly improve the dynamic balance of MMP-1/TIMP-1,skin elasticity and skin physiological indexes in patients with acne vulgaris receiving non-ablative fractional 1 565 nm laser,with good safety.关键词
夫西地酸软膏/非剥脱性点阵1565nm激光/寻常痤疮/基质金属蛋白酶1/基质金属蛋白酶组织抑制因子-1/皮肤弹性Key words
fusidic acid ointment/non-ablative fractional 1 565 nm laser/acne vulgaris/matrix metalloproteinase-1/tissue inhibitor of metalloproteinases-1/elasticity of skin分类
医药卫生引用本文复制引用
郑永青,焦志刚,汤腾雁,任书娟..夫西地酸软膏在非剥脱性点阵1565nm激光治疗的寻常痤疮患者中的临床研究[J].中国临床药理学杂志,2025,41(16):2275-2280,6.基金项目
河南省医学科技攻关计划基金资助项目(LHGJ20210898) （LHGJ20210898）
