中风与神经疾病杂志2025，Vol.42Issue(9)：777-782,6.DOI:10.19845/j.cnki.zfysjjbzz.2025.0147
远隔缺血适应治疗急性缺血性卒中机械取栓术后患者的安全性和有效性研究
Safety and efficacy of remote ischemic conditioning in patients with acute ischemic stroke undergoing mechanical thrombectomy
摘要
Abstract
Objective To investigate the safety and efficacy of remote ischemic conditioning(RIC)in the treat-ment of patients with acute ischemic stroke undergoing mechanical thrombectomy.Methods This was a single-center ran-domized parallel-controlled clinical study.A total of 40 patients with anterior circulation large-vessel occlusive ischemic stroke who were admitted to Baoji High-Tech Hospital within 24 hours after onset and underwent emergency mechanical thrombectomy from July 2023 to July 2024 were enrolled and randomly assigned to the experimental group and the control group at a ratio of 1∶1.The patients in the experimental group received standardized RIC treatment(cuff pressure 200 mmHg),while those in the control group received sham RIC intervention(cuff pressure 60 mmHg),and the course of treatment was 7 days for both groups.The two groups were compared in terms of baseline information,safety assessment indicators(including hemorrhagic transformation,symptomatic intracranial hemorrhage,and adverse events),and effi-cacy evaluation indicators[including NIHSS score,Barthel index,and mRS score after 7 days of treatment,as well as the proportion of patients with good prognosis(an mRS score of 0‒2)and excellent prognosis(an mRS score of 0‒1)at follow-up on day 90].Results A total of 39 patients were finally included in the analysis,with 19 in the experimental group and 20 in the control group.At follow-up on day 90,3 patients were lost to follow-up,and 18 patients in each group were in-cluded in the analysis.There were no significant differences between the two groups in all baseline data(P>0.05)except sex(P=0.048).The safety analysis showed that during hospitalization,there were no deaths in either group,and there were no significant differences in hemorrhagic transformation,symptomatic intracranial hemorrhage,and adverse events between the two groups(P>0.05).One patient in the control group and 2 patients in the experimental group died at follow-up on day 90,with no significant difference between the two groups(P>0.999).The efficacy analysis showed that after 7 days of treatment,there were no significant differences in NIHSS score,Barthel index,and mRS score between the two groups(P>0.05).At follow-up on day 90 after surgery,10 patients in the experimental group and 9 patients in the control group had a good prognosis(55.6%vs 50.0%,P>0.99),and 10 patients in the experimental group and 6 patients in the control group had an excellent prognosis(55.6%vs 33.3%,P=0.315).Conclusion RIC has good safety and efficacy in the treatment of patients with acute ischemic stroke after mechanical thrombectomy,with a tendency to improve 90-day functional prognosis.关键词
远隔缺血适应/缺血性卒中/机械取栓/预后Key words
Remote ischemic condition-ing/Ischemic stroke/Mechanical thrombec-tomy/Prognosis分类
医药卫生引用本文复制引用
郝涛,张会平,潘艳艳,张敏,曲瑒,柳嘉诚,雷双银..远隔缺血适应治疗急性缺血性卒中机械取栓术后患者的安全性和有效性研究[J].中风与神经疾病杂志,2025,42(9):777-782,6.基金项目
吉林大学研究生创新基金资助项目(2025CX292) （2025CX292）
