中国全科医学2025，Vol.28Issue(35)：4501-4510,10.DOI:10.12114/j.issn.1007-9572.2024.0392
乳酸化修饰在年龄相关性疾病中的研究新进展
Research Progress of Lactylation in Age-related Diseases
摘要
Abstract
Lactylation(Kla)is a novel mechanism of protein post-translational modification,which is formed by covalent coupling of lactate produced by glycolysis with lysine residues,mainly including histone lactylation and non-histone lactylation.At present,the study found that the main through regulating gene transcription and protein expression and subcellular localization to participate in the process of life activity in the cell.With the increasing of age,lactate metabolism in multiple organs of the body was disordered,and recent studies found that lactylation mediated by it could participate in the occurrence and development of a variety of age-related diseases.Therefore,this paper aimed to review the functional and mechanistic studies of lactylation in age-related diseases.关键词
乳酸化修饰/乳酸/年龄相关性疾病/组蛋白乳酸化/非组蛋白乳酸化Key words
Lactylation/Lactic acid/Age-related diseases/Histone lactylation/Non-histone lactylation分类
医药卫生引用本文复制引用
吴苗苗,李鹏飞,徐林慧,康丽华,季敏,王勇,管怀进..乳酸化修饰在年龄相关性疾病中的研究新进展[J].中国全科医学,2025,28(35):4501-4510,10.基金项目
国家自然科学基金资助项目(81974129,82171038) （81974129,82171038）
南通市科技项目(MSZ20177) （MSZ20177）
江苏省医学重点学科(JSDW202245) （JSDW202245）
