中风与神经疾病杂志2025，Vol.42Issue(9)：796-806,11.DOI:10.19845/j.cnki.zfysjjbzz.2025.0150
醒脑静注射液在脑卒中后意识障碍治疗中的疗效和安全性:系统评价和Meta分析
Efficacy and safety of Xingnaojing Injection in treatment of post-stroke disorders of consciousness:A systematic review and meta-analysis
摘要
Abstract
Objective To systematically evaluate the efficacy and safety of Xingnaojing Injection(XNJ)in the treatment of post-stroke disorders of consciousness(PSDOC).Methods PubMed,Embase,the Cochrane Library,Web of Science,VIP,CNKI,Wanfang Data,and SinoMed were searched for related randomized controlled trials(RCT)pub-lished up to July 2025.RevMan 5.4 and Stata 16.0 were used for data extraction and analysis.Results A total of 48 RCT were included,with 4 570 patients in total.The RCT included had relatively low overall risk of bias.The meta-analysis showed that compared with conventional treatment alone,XNJ combined with conventional treatment significantly improved the Glasgow Coma Scale(GCS)score of patients with PSDOC(mean difference=2.62,95%confidence inter-val:2.37‒2.86,I²=66%,P<0.000 01).The subgroup analyses showed that XNJ administered at three dosages(20 ml,30 ml,40 ml)and for different treatment durations(1 week,2 weeks,4 weeks)could effectively improve the GCS score of patients,and it also showed efficacy in patients with hemorrhagic/ischemic stroke and disorders of consciousness.Nine RCT reported the adverse reactions including nausea,rash,and mild dizziness during the trial,which were resolved after the infusion rate was slowed down.Conclusion XNJ is a safe and effective therapy for improving consciousness in pa-tients with PSDOC.关键词
脑卒中/醒脑静注射液/意识障碍/意识功能/Meta分析Key words
Stroke/Xingnaojing Injection/Disorders of consciousness/Consciousness function/Meta-analysis分类
医药卫生引用本文复制引用
陈良胜,龚成,彭徐苗,吴文娟,朱福宇,罗云..醒脑静注射液在脑卒中后意识障碍治疗中的疗效和安全性:系统评价和Meta分析[J].中风与神经疾病杂志,2025,42(9):796-806,11.基金项目
江西省中医药管理局科技项目(2021A309) （2021A309）
