中风与神经疾病杂志2025，Vol.42Issue(9)：823-829,7.DOI:10.19845/j.cnki.zfysjjbzz.2025.0153
超声引导下星状神经节阻滞对颈动脉内膜切除术患者炎性因子和术后恢复质量的影响
Effect of ultrasound-guided stellate ganglion block on inflammatory factors and postoperative recovery quality in patients undergoing carotid endarterectomy
摘要
Abstract
Objective To investigate the effect of stellate ganglion block(SGB)on postoperative recovery qual-ity,serum inflammatory factors,and neuron-specific enolase(NSE)in patients undergoing carotid endarterectomy.Methods A total of 92 male or female patients who underwent elective carotid endarterectomy in The Affiliated Su-zhou Hospital of Nanjing Medical University were enrolled,with an age of 40‒75 years and an ASA grade of Ⅱ‒Ⅲ.The patients were randomly divided into SGB group with 46 patients and control group with 46 patients.The patients in the SGB group received SGB treatment before carotid endarterectomy,while those in the control group did not un-dergo SGB.ELISA was used to measure the serum levels of interleukin-1β(IL-1β),interleukin-6(IL-6),interleu-kin-10(IL-10),and NSE immediately after anesthesia intubation,before blocking,after vessel opening,at the end of surgery,and at 6 and 24 hours after surgery.Major adverse cardiac events during the perioperative period and the rate of use of vasoactive agents were recorded for both groups,as well as Mini-Mental State Examination(MMSE)score,Montreal Cognitive Assessment(MoCA)score,and Quality of Recovery-15(QoR-15)score on day 1 before surgery and on days 3 and 7 after surgery.Results Compared with the control group,the SGB group had signifi-cantly lower serum levels of IL-1β,IL-6,and NSE and a significantly higher serum level of IL-10(P<0.05).During the perioperative period,compared with the control group,the SGB group had significantly lower incidence rates of hypertension,nausea and vomiting,and hypoxemia and a significantly rate of use of vasoactive agents(P<0.05).The SGB group had significantly higher MMSE,MoCA,and QoR-15 scores than the control group on day 7 after sur-gery(P<0.05).Conclusion For patients undergoing carotid endarterectomy,SGB can effectively alleviate periop-erative inflammatory response,reduce the serum level of NSE,improve the quality of short-term postoperative recov-ery,and reduce adverse events.关键词
星状神经节阻滞/颈内动脉切除术/术后恢复质量/炎症反应/神经元特异性烯醇化酶Key words
Stellate ganglion block/Carotid endarterectomy/Postoperative recovery quality/In-flammatory response/Neuron-specific enolase分类
医药卫生引用本文复制引用
杨昌建,韩丽,赵月,袁晨,杨芬,沈军,谢阳..超声引导下星状神经节阻滞对颈动脉内膜切除术患者炎性因子和术后恢复质量的影响[J].中风与神经疾病杂志,2025,42(9):823-829,7.基金项目
江苏省自然科学基金项目(BE2017661) （BE2017661）
