中国比较医学杂志2025，Vol.35Issue(9)：91-98,8.DOI:10.3969/j.issn.1671-7856.2025.09.009
基于家兔氯化钡法与豚鼠哇巴因法的心律失常模型技术比较和教学应用研究
A study on the technical comparison and pedagogical application of an arrhythmia model based on barium chloride-induced rabits and ouabain-induced guinea pigs
摘要
Abstract
Animal models of cardiac arrhythmia are important tools for analyses of antiarrhythmic drug mechanisms and medical laboratory teaching.In this study,two major models,namely,barium chloride-induced arrhythmia in rabbits and ouabain-induced arrhythmia in guinea pigs,were systematically compared in terms of technical principles,modeling method,and indexes.By optimizing electrocardiographic parameters,standardizing arrhythmia grading criteria,and introducing quantitative analysis method,we revealed differences between the two models in terms of ion channel mechanisms,drug targets,and applicability to teaching.The barium chloride model was characterized by rapidly induced ventricular arrhythmia,which is suitable for the observation of acute drug efficacy.The ouabain model simulated the development of progressive arrhythmia,which is suitable for the study of the preventive effects of anti-arrhythmic drugs.This study provides a technical reference for the selection of arrhythmia models,optimization process,and mechanistic analyses in medical experimental teaching and is of great significance for improving the electrophysiology experimental skills of medical students.关键词
心律失常/实验教学/氯化钡模型/哇巴因模型/动物模型Key words
arrhythmia/experimental teaching/BaCl2 model/ouabain model/animal model分类
医药卫生引用本文复制引用
饶玉良,马淑兰,张亚东,严钰锋..基于家兔氯化钡法与豚鼠哇巴因法的心律失常模型技术比较和教学应用研究[J].中国比较医学杂志,2025,35(9):91-98,8.基金项目
教育部产学合作协同育人项目(220901282154531) （220901282154531）
教育部基础学科拔尖学生培养计划2.0研究课题(20212025). （20212025）
