中国比较医学杂志2025，Vol.35Issue(9)：99-112,14.DOI:10.3969/j.issn.1671-7856.2025.09.010
犬尿氨酸通路对阿尔茨海默病的影响机制研究进展
Research progress on the mechanism of the kynurenine pathway in Alzheimer's disease
摘要
Abstract
Alzheimer's disease(AD)is a typical progressive neurodegenerative disease,mainly manifesting as severe cognitive dysfunction,and involving memory,thought processes,and emotion.The kynurenine pathway(KP)is one of the main metabolic pathways of tryptophan,which can be divided into neurotoxicity and neuroprotective branches.Increasing evidence has suggested that KP is involved in the pathogenesis of AD.This review considers the role of KP in the pathogenesis of AD,with reference to the relevant literature on KP interventions in AD in the PubMed database.The result will provide an important reference for the use of KP as a target for AD drug development.关键词
犬尿氨酸通路/阿尔茨海默病/喹啉酸/犬尿烯酸Key words
kynurenine pathway/Alzheimer's disease/quinolinic acid/kynurenic acid分类
医药卫生引用本文复制引用
陈启妮,马玉杰,赖瑶娜,高铭凰,徐子乔,杨虹颖,李伟荣,王奇..犬尿氨酸通路对阿尔茨海默病的影响机制研究进展[J].中国比较医学杂志,2025,35(9):99-112,14.基金项目
国家自然科学基金面上项目(82274616). （82274616）
