中国比较医学杂志2025，Vol.35Issue(9)：113-121,9.DOI:10.3969/j.issn.1671-7856.2025.09.011
间充质干细胞外泌体与阿尔茨海默病研究进展
Research progress on mesenchymal stem cell-derived extracellular vesicles and Alzheimer's disease
摘要
Abstract
With population aging worldwide,Alzheimer's disease(AD)has become a serious human health issue.Owing in part to the complexity of the pathogenesis of AD,effective therapeutic options are lacking.Mesenchymal stem cell-derived exosomes(MSC-Exos)have powerful regenerative properties and repair functions,providing a new direction for treatment.They are donor-derived,easily stored,natural carriers,with low immunogenicity and a low risk of tumor formation.They have shown great potential in the treatment of AD and post-treatment rehabilitation.This article introduces the pathological mechanisms of AD and characteristics of MSC-Exos,provides a detailed review of the roles of MSC-Exos in the treatment of AD,including anti-inflammatory effects,immunomodulatory effects,and related signaling pathway modulation,and summarizes recent research progress,with the aim of providing a basis for the development of novel therapeutic approaches to AD.关键词
外泌体/间充质干细胞/阿尔茨海默病Key words
exosomes/mesenchymal stem cells/Alzheimer's disease分类
医药卫生引用本文复制引用
刘思睿,王亚东,陈祉伊,韩景献,张雪竹..间充质干细胞外泌体与阿尔茨海默病研究进展[J].中国比较医学杂志,2025,35(9):113-121,9.基金项目
国家自然科学基金(30630074,82174492). （30630074,82174492）
