中国比较医学杂志2025，Vol.35Issue(9)：134-144,11.DOI:10.3969/j.issn.1671-7856.2025.09.013
AMPK信号通路在帕金森病调控及治疗中的研究进展
Research progress on the regulation and treatment of Parkinson's disease via the AMPK signaling pathway
摘要
Abstract
Parkinson's disease(PD),the second most common neurodegenerative disorder,involves dopaminergic neuron degeneration,abnormal α-synuclein aggregation,and energy metabolic disruption.AMP-activated protein kinase(AMPK),a key cellular energy metabolic regulator,has multiple roles in PD progression.This paper explores the structure and function of AMPK and its regulatory mechanisms in PD,including its roles in modulating neuronal energy metabolism,mediating mitochondrial function,inhibiting oxidative stress,inducing autophagy,and regulating neuroinflammation and apoptosis.Potential AMPK-based PD therapies are also reviewed,including natural products(e.g.,resveratrol,curcumin),gene therapy,and targeted delivery systems,while noting the need to precisely control the dual effects of AMPK(e.g.,overactivation causes energy stress).Future research should focus on clarifying interactions between AMPK and other pathways(e.g.,SIRT1 and NF-κB)and improving the spatiotemporal specificity of targeted treatments for clinical translation.This study offers crucial theoretical support for understanding mechanisms underlying PD and developing AMPK-targeted therapies.关键词
帕金森病/AMP活化蛋白激酶(AMPK)/信号通路/神经保护作用/线粒体功能Key words
Parkinson's disease/AMP-activated protein kinase/signaling pathway/neuroprotective effects/mitochondrial function分类
医药卫生引用本文复制引用
孙晨枫,任彬彬..AMPK信号通路在帕金森病调控及治疗中的研究进展[J].中国比较医学杂志,2025,35(9):134-144,11.基金项目
中医药传承与创新人才工程(仲景工程)(CZ0325-10) （仲景工程）
2022年度河南省中医药拔尖人才培养项目专项课题(2022 ZYBJ09). （2022 ZYBJ09）
