中国实用妇科与产科杂志2025，Vol.41Issue(9)：873-878,6.DOI:10.19538/j.fk2025090103
妊娠合并血栓性血小板减少性紫癜的早期诊断与干预
Early diagnosis and intervention of pregnancy-associated thrombotic thrombocytopenic purpura
摘要
Abstract
Pregnancy-associated thrombotic thrombocyto-penic purpura(TTP)is a rare obstetric complication charac-terized by thrombocytopenia,microangiopathic hemolytic anemia,and multi-organ dysfunction.The hypercoagulable state of pregnancy,combined with deficient or inhibited ADAMTS13 enzyme activity,significantly exacerbates dis-ease risk,resulting in high mortality if untreated.This arti-cle systematically reviews the pathological mechanisms,early diagnostic biomarkers,and intervention strategies for gestational TTP.A multidisciplinary clinical management pathway is proposed and the future research directions based on the latest scientific advances are discussed.关键词
血栓性血小板减少性紫癜/微血管溶血性贫血/血管性血友病因子裂解蛋白酶/血浆置换Key words
thrombotic thrombocytopenic purpura/microangiopathic hemolytic anemia/ADAMTS13/plasma exchange分类
医药卫生引用本文复制引用
陈嘉敏,习芳芳,罗琼..妊娠合并血栓性血小板减少性紫癜的早期诊断与干预[J].中国实用妇科与产科杂志,2025,41(9):873-878,6.基金项目
国家自然科学基金(82471713) National Natural Science Foundation of China(82471713) （82471713）
