中国医学创新2025，Vol.22Issue(27)：174-178,5.DOI:10.3969/j.issn.1674-4985.2025.27.041
正念减压联合艾司西酞普兰对慢性心力衰竭伴焦虑抑郁患者的影响
Effect of Mindfulness-Based Stress Reduction Combined with Escitalopram on Patients with Chronic Heart Failure Accompanied by Anxiety and Depression
摘要
Abstract
Objective:To evaluate the effects of mindfulness-based stress reduction in conjunction with Escitalopram on patients with chronic heart failure accompanied by anxiety and depression.Method:A total of 80 patients suffering from both chronic heart failure accompanied by anxiety and depression who were hospitalized in the Department of Cardiovascular Medicine,Gao'an People's Hospital from March 2023 to October 2024 were selected.They were randomly divided into a control group(40 cases)and a treatment group(40 cases)using a random number table method.The control group received conventional chronic heart failure treatment,while the treatment group received mindfulness-based stress reduction combined with Escitalopram Oxalate on this basis,the treatment lasted for 6 weeks.Clinical efficacy,psychological status(HAMA and HAMD),quality of life[the Minnesota living with heart failure questionnaire(MLHFQ)],and adverse reactions were compared between the two groups.Result:After treatment,the treatment group exhibited a markedly higher overall clinical efficacy(92.50%)compared to the control group(72.50%),with a statistically significant difference(P<0.05).After treatment,HAMA and HAMD scores in the treatment group[(11.37±2.11),(9.32±1.59)points]were markedly lower than those in the control group[(16.21±2.48),(11.89±1.67)points],with statistically significant differences(P<0.05).After treatment,MLHFQ scores in the treatment group,including physical symptoms,emotional state,and physical activity scores[(15.23±3.95),(13.02±3.17),(18.76±3.38)points],were notably lower than those found in the control group[(18.03±3.89),(15.21±3.22),(22.58±3.59)points],with statistically significant differences(P<0.05).The treatment group had a significantly lower overall incidence of adverse reactions(5.00%)compared to the control group(22.50%),with a statistically significant difference(P<0.05).Conclusion:Mindfulness-based stress reduction combined with Escitalopram can significantly enhance clinical efficacy,effectively alleviate symptoms of anxiety and depression,improve quality of life,and demonstrate high safety.关键词
慢性心力衰竭/焦虑/抑郁/正念减压/草酸艾司西酞普兰Key words
Chronic heart failure/Anxiety/Depression/Mindfulness-based stress reduction/Escitalopram Oxalate引用本文复制引用
梁锦标,陶锴,廖萍..正念减压联合艾司西酞普兰对慢性心力衰竭伴焦虑抑郁患者的影响[J].中国医学创新,2025,22(27):174-178,5.基金项目
宜春市指导性科技计划项目(JXYC2023ZDJH2912) （JXYC2023ZDJH2912）
