中国医学创新2025，Vol.22Issue(28)：1-5,5.DOI:10.3969/j.issn.1674-4985.2025.28.001
盐酸氨溴索、美洛西林钠舒巴坦钠联合血必净治疗重症肺炎合并呼吸衰竭的临床研究
Clinical Study on the Treatment of Severe Pneumonia Complicated with Respiratory Failure with Ambroxol Hydrochloride,Mezlocillin Sodium and Sulbactam Sodium Combined with Xuebijing
摘要
Abstract
Objective:To investigate the efficacy of Ambroxol Hydrochloride,Mezlocillin Sodium and Sulbactam Sodium combined with Xuebijing in the treatment of severe pneumonia complicated with respiratory failure(RF).Method:A total of 90 patients with severe pneumonia complicated with RF admitted to Ji'an Central People's Hospital(Shanghai East Hospital Ji'an Hospital)from June 2020 to June 2024 were selected and randomly divided into group A(treated with Mezlocillin Sodium and Sulbactam Sodium),group B(treated with Mezlocillin Sodium and Sulbactam Sodium combined with Ambroxol Hydrochloride),and group C(treated with Xuebijing Injection on the basis of group B),with 30 cases in each group.The clinical efficacy,blood gas indicators,clinical indicators,inflammatory indicators,traditional Chinese medicine syndrome scores and the incidence of adverse reactions of the three groups were compared.Result:After treatment,PaCO2,procalcitonin(PCT),systemic immune inflammation index(SII),traditional Chinese medicine syndrome score and erythrocyte sedimentation rate(ESR)in the three groups were all lower than those before treatment,and group C<group B<group A,PaO2,oxygenation index(PaO2/FiO2),SaO2,and superoxide dismutase(SOD)were all higher compared with those before treatment,and group C>group B>group A,with statistically significant differences(P<0.05).The shortness of breath relief time,cough of phlegm relief time and mechanical ventilation time in group C were better than those in group A and group B,and the total effective rate was higher than those in group A and group B,with statistically significant differences(P<0.05).There was no statistically significant difference in the incidence of adverse reactions among the three groups(P>0.05).Conclusion:Ambroxol Hydrochloride,Mezlocillin Sodium and Sulbactam Sodium combined with Xuebijing has a significant effect in the treatment of severe pneumonia complicated with RF,which can improve the lung function,enhance the immune function,and reduce the inflammatory response.关键词
盐酸氨溴索/美洛西林钠舒巴坦钠/血必净/重症肺炎/呼吸衰竭Key words
Ambroxol Hydrochloride/Mezlocillin Sodium and Sulbactam Sodium/Xuebijing/Severe pneumonia/Respiratory failure引用本文复制引用
徐小妹,张文,刘峰,邓茂林..盐酸氨溴索、美洛西林钠舒巴坦钠联合血必净治疗重症肺炎合并呼吸衰竭的临床研究[J].中国医学创新,2025,22(28):1-5,5.基金项目
吉安市指导性科技计划项目(20244-049324) （20244-049324）
