中国医学创新2025，Vol.22Issue(28)：6-9,4.DOI:10.3969/j.issn.1674-4985.2025.28.002
甲泼尼龙联合微生态制剂治疗儿童过敏性紫癜的效果
Effect of Methylprednisolone Combined with Microecologics in the Treatment of Allergic Purpura in Children
摘要
Abstract
Objective:To investigate the effect of Methylprednisolone combined with microecologics in the treatment of allergic purpura in children.Method:A total of 60 children with allergic purpura admitted to Ganzhou Women and Children's Health Care Hospital from January 2020 to January 2023 were included in the study.They were grouped by the ball-touching method,those with odd numbers were included in the control group(n=30),and those with even numbers were included in the observation group(n=30).The control group was treated with Methylprednisolone,and the observation group was treated with Methylprednisolone combined with microecologics.The clinical efficacy,symptoms disappearance time,humoral immune function(IgA,IgG,IgM),inflammatory factors(IL-4,IFN-γ)before and after 14 days of treatment and the occurrence of adverse reactions were compared between the two groups.Result:The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).The disappearance time of abdominal pain,purpura and joint swelling and pain in the observation group were earlier than those in the control group(P<0.05).The levels of IgA,IL-4 and IFN-γ in the observation group after 14 days of treatment were lower than those in the control group(P<0.05).During the treatment process,no adverse reactions occurred in any of the children.Conclusion:Methylprednisolone combined with microecologics is more effective in the treatment of allergic purpura in children than Methylprednisolone alone.It can relieve symptoms more quickly,improve immune function,reduce the levels of inflammatory factors,and no adverse reactions have been observed.关键词
甲泼尼龙/微生态制剂/儿童/过敏性紫癜/免疫功能/炎症因子Key words
Methylprednisolone/Microecologics/Children/Allergic purpura/Immune function/Inflammatory factors引用本文复制引用
廖晓卿,谢美燕,何琳..甲泼尼龙联合微生态制剂治疗儿童过敏性紫癜的效果[J].中国医学创新,2025,22(28):6-9,4.基金项目
赣州市科技计划项目(20211ZDX2559) （20211ZDX2559）
