中国全科医学2025，Vol.28Issue(35)：4409-4413,5.DOI:10.12114/j.issn.1007-9572.2025.0091
2型糖尿病患者心率变异性与脑梗死的相关性研究
The Correlation between Heart Rate Variability and Cerebral Infarction in Patients with Type 2 Diabetes Mellitus
摘要
Abstract
Background Heart rate variability(HRV)is associated with cerebral infarction,although this association has been less studied in patients with type 2 diabetes mellitus(T2DM).Objective To explore the correlation between HRV and cerebral infarction in T2DM patients.Methods A total of 577 T2DM patients hospitalized in Ningbo No.2 Hospital between January 2020 and August 2022 were selected.According to the presence or absence of cerebral infarction,patients were divided into the cerebral infarction group and non-cerebral infarction group.The general data and laboratory results were collected.All patients received 24-hour Holter monitoring.HRV parameters,including the standard deviation of normal-to-normal intervals(SDNN),the root mean square of successive RR interval differences(rMSSD),and the percent of adjacent RR intervals with a difference more than 50 ms(PNN50)were recorded.Multivariate Logistic regression analysis was used to analyze the correlation between HRV and cerebral infarction.Patients were further divided into the decreased SDNN group(SDNN<100 ms)and normal SDNN group(SDNN≥100 ms)based on the SDNN measurements in HRV,and the correlation with cerebral infarction was explored.Results A total of 577 T2DM patients were enrolled,including 287 cases in the cerebral infarction group and 290 cases in non-cerebral infarction group.Multivariate Logistic regression analysis showed that SDNN was the independent influencing factor for cerebral infarction in T2DM patients(OR=0.970,95%CI=0.961-0.979,P<0.05).There were 264 cases in the decreased SDNN group and 313 cases in the normal SDNN group.Multivariate logistic regression showed a significantly higher risk of cerebral infarction in the decreased SDNN group than the normal SDNN group(OR=4.164,95%CI=2.769-6.262,P<0.05).Conclusion The reduction of HRV parameters in T2DM patients is closely correlated to cerebral infarction.With the reduction of SDNN,the risk of cerebral infarction in patients increases.关键词
2型糖尿病/脑梗死/心率变异性/全部正常窦性心搏间期的标准差Key words
Type 2 diabetes mellitus/Cerebral infarction/Heart rate variability/Standard deviation of normal-to-normal intervals分类
医药卫生引用本文复制引用
徐君,张劼..2型糖尿病患者心率变异性与脑梗死的相关性研究[J].中国全科医学,2025,28(35):4409-4413,5.基金项目
2023年宁波市国际合作项目(2023H024) （2023H024）
浙江省医药卫生科技计划项目(2021KY1012) （2021KY1012）
