中国中医急症2025，Vol.34Issue(9)：1462-1468,7.DOI:10.3969/j.issn.1004-745X.2025.09.005
补肾活血汤治疗腰椎间盘突出症的系统评价与试验序贯分析
Systematic Review and Trial Sequential Analysis of Bushen Huoxue Decoction for Lumbar Disc Herniation
摘要
Abstract
Objective:To evaluate the efficacy and safety of Bushen Huoxue Decoction(BSHXD)in treating lum-bar disc herniation(LDH)through a systematic review and trial sequential analysis(TSA).Methods:Databases including CBM,CNKI,VIP,Wanfang,PubMed,Medline,and Web of Science were electronically searched from Jan-uary 1,2004,to December 31,2024,for studies on the clinical efficacy of BSHXD in treating LDH.Retrieved liter-ature was screened,and data were extracted.Outcome data were analyzed using RevMan 5.4 and TSA 0.9.5 for me-ta-analysis and TSA.Results:40 studies involving 1 184 patients were included.Meta analysis showed that,com-pared with the control group,the BSHXD group had a significantly higher total effective rate[RR=1.14,95％CI(1.05,1.24),P=0.003],significantly reduced visual analog scale(VAS)scores for lumbar pain[SMD=-0.96,95％CI(-1.41,-0.52),P＜0.000 1],and significantly improved Japanese Orthopaedic Association(JOA)scores[SMD=1.27,95％CI(0.85,1.68),P＜0.000 01]and Oswestry Disability Index(ODI)scores[SMD=-2.66,95％CI(-4.19,-1.14),P=0.000 6].No significant difference was observed in the incidence of adverse events.Conclu-sion:BSHXD demonstrates significant efficacy and good safety in treating lumbar disc herniation,and the conclu-sion is robust against false-positive results.关键词
腰椎间盘突出症/补肾活血汤/疗效/安全性/系统评价/Meta分析/试验序贯分析Key words
Lumbar disc herniation/Bushen Huoxue Decoction/Efficacy/Safety/Systematic review/Meta analy-sis/Trial sequential analysis分类
医药卫生引用本文复制引用
马明明,朱立国,于杰,路广琦,周帅琪,毛瀚泽,俞张镜泽,李靖,孙馨悦,刘亚坤,胡家铭..补肾活血汤治疗腰椎间盘突出症的系统评价与试验序贯分析[J].中国中医急症,2025,34(9):1462-1468,7.基金项目
国家重点研发计划项目(2021YFC1712800) （2021YFC1712800）
中国中医科学院科技创新工程项目(CI2021B010) （CI2021B010）
