中国中医急症2025，Vol.34Issue(9)：1469-1473,1478,6.DOI:10.3969/j.issn.1004-745X.2025.09.006
基于中医"气热传营"病机探究C反应蛋白/血小板计数对脓毒症死亡结局的影响
Evaluating the Predictive Value of CRP/PLT on Mortality Outcomes in Sepsis Based on the Traditional Chinese Medicine Pathogenesis of"Heat of Qifen Invading Yingfen"
摘要
Abstract
Objective:To evaluate the predictive value of the C-reactive protein to platelet count ratio(CRP/PLT)for mortality outcomes in sepsis based on the Traditional Chinese Medicine(TCM)pathogenesis of"heat of qifen invading yingfen".Methods:A retrospective analysis was conducted on data from 237 sepsis patients admit-ted to Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,between January 1,2019,and November 1,2024.Patients were divided into survival and non-survival groups based on 28-day outcomes.The patient general information,clinical characteristics,and laboratory parameters were analyzed,and the CRP/PLT ra-tios on day 1 and day 7,as well as the degree of change in the ratio between these days,were calculated.Various statistical methods,including group comparison analysis,ROC curve analysis,survival analysis,LASSO regression,and Cox regression analysis,were employed to evaluate the impact of these indicators on disease progression and prognosis,and to identify independent predictive factors.Results:There were significant differences between the survival and non-survival groups in age,systolic blood pressure,diastolic blood pressure,and other parameters,as well as in the CRP/PLT ratios on day 1 and day 7 and the degree of change in the ratio.ROC curve analysis showed high diagnostic value for the day 7 CRP/PLT ratio(AUC=0.791)and the degree of change(AUC=0.713).Survival analysis after stratification revealed that patients in the high CRP/PLT group(day 1 and day 7)and the high ratio-change group had significantly lower survival rates compared with the low-value groups.Multivariate Cox regression analysis identified a day 7 CRP/PLT ratio ≥ 0.569(HR=2.25,95％CI:1.21～4.18)and a ratio change degree ≥ 0.097(HR=1.96,95％CI:1.11～3.46)as independent risk factors for reduced survival.Conclu-sion:CRP/PLT ratio demonstrates significant value in early prediction of sepsis progression.CRP/PLT ratio on day 7 and the degree of its change are effective indicators for early assessment of mortality risk in sepsis patients.关键词
脓毒症/气热传营/C反应蛋白/血小板/死亡预测Key words
Sepsis/Heat of qifen invading yingfen/C-reactive protein/Platelets/Mortality prediction分类
医药卫生引用本文复制引用
陈腾飞,丁茂裕,杨玉媚,杨钦翔,刘清泉..基于中医"气热传营"病机探究C反应蛋白/血小板计数对脓毒症死亡结局的影响[J].中国中医急症,2025,34(9):1469-1473,1478,6.基金项目
中华中医药学会雏鹰计划中医青年临床人才研修项目(CYJH2024006) （CYJH2024006）
首都医科大学附属北京中医医院科技发展基金重点资助项目(LYZD202307) （LYZD202307）
