神经药理学报2025，Vol.15Issue(4)：1-7,7.DOI:10.3969/j.issn.2095-1396.2025.04.001
从巨噬细胞极化与衡法理论相关性论治慢性肾衰竭的研究进展
Decoction Research Progress on the Treatment of Chronic Renal Failure from the Perspective of the Correlation between Macrophage Polarization and the Henyfa Theory
摘要
Abstract
Chronic renal failure(CRF),as the end-stage of various chronic kidney diseases,involves complex pathological mechanisms such as renal fibrosis and inflammatory responses,making it one of the difficult clinical diseases.The"Hengfa"theory founded by National Master of Traditional Chinese Medicine Yan Dexin takes"regulating qi and blood,balancing yin and yang"as the core,emphasizing the prevention and treatment of diseases by balancing the circulation of qi,blood,and body fluids in the body.Modern studies have shown that the imbalance of macrophage polarization status(M1/M2 type)plays a key role in the process of renal fibrosis in CRF,and Hengfa prescription(Gushen Xiezhuo Decoction)may improve CRF pathological damage by regulating macrophage polarization and inhibiting the inflammation-fibrosis cascade reaction.Starting from the core connotation of the Hengfa theory and combining with the molecular mechanism of macrophage polarization,this paper systematically discusses the correlation between the two in the diagnosis and treatment of CRF,providing new ideas for the integrated traditional Chinese and western medicine treatment of CRF.关键词
慢性肾衰竭/巨噬细胞极化/衡法/固肾泄浊方/肾纤维化Key words
chronic renal failure/macrophage polarization/Hengfa theory/Gushen Xiezhuo Decoction/renal fibrosis分类
医药卫生引用本文复制引用
祝昌昊,张文雷,唐阁..从巨噬细胞极化与衡法理论相关性论治慢性肾衰竭的研究进展[J].神经药理学报,2025,15(4):1-7,7.基金项目
国家自然科学基金项目(No.81503393) （No.81503393）
天津市中医经典传承高级人才研修项目(津卫中便函[2021]642号) （津卫中便函[2021]642号）
