神经药理学报2025，Vol.15Issue(4)：8-16,9.DOI:10.3969/j.issn.2095-1396.2025.04.002
溃疡性结肠炎动物模型及评价指标
Animal Models of Ulcerative Colitis and Evaluation Indicators
马琳 1范荣珍 1李炜 2张丹参1
作者信息
- 1. 河北科技大学化学与制药工程学院,石家庄,050018,中国
- 2. 河北北方学院药学院,张家口,075000,中国
- 折叠
摘要
Abstract
Ulcerative colitis(UC)is a chronic non-specific intestinal disease with lesions involving the rectum and colon,and clinical manifestations include abdominal pain,diarrhea,and muco-purulent and bloody stools.In recent years,the incidence of UC has surged,which seriously affects the quality of life of patients.The pathogenesis of ulcerative colitis is complex and diverse,involving environmental factors,genetic factors,body immunity and psychological factors.In order to deeply investigate the pathogenesis and regulatory mechanism of this disease and develop targeted therapeutic drugs,it is particularly important to construct suitable animal experimental models.In this paper,we summarize the current selection of animals inducing ulcerative colitis,modeling methods,and model evaluation indexes,in order to provide more feasible solutions for scientific research experiments and clinical practice,and at the same time to provide reference for researchers in related fields to follow up the researchers.关键词
溃疡性结肠炎/动物模型/造模方法/评价指标Key words
ulcerative colitis/animal model/modeling method/evaluation indicators分类
医药卫生引用本文复制引用
马琳,范荣珍,李炜,张丹参..溃疡性结肠炎动物模型及评价指标[J].神经药理学报,2025,15(4):8-16,9.
