神经药理学报2025，Vol.15Issue(5)：1-9,9.DOI:10.3969/j.issn.2095-1396.2025.05.001
备案制指导下院内制剂温阳化浊颗粒制备工艺研究
Research on the Preparation Process of Wenyang Huazhuo-Pellet Under the Guidance of Intra-Hospital Preparation Filing System
摘要
Abstract
Objective:To investigate the preparation process of zhongyu-pellet.Methods:Single-factor and orthogonal experimental methods were used to explore the extraction and pelletizing processes.The optimal extraction and pelletizing processes were determined and validated through three pilot-scale batches.Results:The optimal preparation processes were determined.Extraction process:Take the prescribed medicinal materials,add water for extraction three times(1.5 hours each time),using 10 times the amount of water for the extractions.Pelletizing process:The extract is dried at 70℃,and maltodextrin is used as the excipient.During granulation,a 3:1 ratio of dry extract powder to excipient is mixed,with the addition of 80%ethanol(17.5 mL).The resulting granules are then vacuum-dried at 80℃for 3 hours.Conclusion:The optimal extractions for the zhongyu-pellet were successfully determined.关键词
温阳化浊颗粒/提取工艺/制粒工艺Key words
wenyang huazhuo-pellet/extraction process/pelletizing process分类
医药卫生引用本文复制引用
瞿晶田,柴士伟,何家琛,陈涛,李宇,王洋,吕明远,李连萍,宋纹,刘芳..备案制指导下院内制剂温阳化浊颗粒制备工艺研究[J].神经药理学报,2025,15(5):1-9,9.基金项目
中药创新能力提升项目(国家中医药管理局中医药科技研究专项) （国家中医药管理局中医药科技研究专项）
