肿瘤药学2025，Vol.15Issue(4)：551-558,8.DOI:10.3969/j.issn.2095-1264.2025.04.16
857例抗肿瘤药物所致不良反应分析
Analysis of 857 cases of ADR caused by anti-tumor drugs
赵晨 1李娜 1王德菊 2史筱倩 1杨柱梅 1孔树佳1
作者信息
- 1. 云南省肿瘤医院 药学部,云南 昆明,650118
- 2. 中国药科大学,江苏 南京,211198
- 折叠
摘要
Abstract
Objective To investigate the characteristics and rules of adverse drug reaction(ADR)caused by anti-tu-mor drugs,and to provide reference for the safe use of anti-tumor drugs in clinical practice.Methods The ADR reports of anti-tumor drugs reported to the National Adverse Drug Reaction Monitoring System in our hospital from January 1,2021 to December 31,2022 were collected.The types of ADR reports,gender and age of patients,route of administra-tion,occurrence time of ADR,types of drugs,tumor status of patients,ADR-involved system/organ and clinical manifes-tations,outcome,association evaluation,occupation of reporter were retrospectively analyzed,and the factors affecting the severity of ADR were correlated.Results Among the 857 ADR reports,627 cases(73.16%)were serious ADRs,230 cases(26.84%)were general ADRs.There were no new ADRs.The tumor stage of the patients and the type of drugs used significantly affected the severity of ADR(P<0.05).Among the ADR reports,there were 421 male cases(49.12%)and 436 female cases(50.88%).Patients aged from 45 to 59 accounted for the highest proportion(49.36%).Intravenous ad-ministration was the main route of administration that causes ADR(96.62%).ADR mostly occurred at 1 to 7 days after medication(30.69%),and the occurrence time varied depending on the type of drug and its toxic manifestations.Cytotox-ic drugs were the most likely type of drugs to cause ADR,among which platinum metals accounted for the highest propor-tion(38.97%).Lung cancer patients made the highest incidence of ADR.The most common system/organ involved in ADR was the hematological system(63.35%).95.10%of the patients with ADR recovered or were improved after treat-ment.The ADR correlation evaluation showed 70.36%of cases were very likely correlated with the drug.Doctors(73.63%)were the main group who reported ADRs in the system.Conclusion Anti-tumor drugs,particularly cytotoxic agents,are associated with a high incidence and severity of ADRs.Clinical practice should enhance targeted monitoring for high-risk patient groups,critical drugs,and serious ADRs.It is suggested that clinical pharmacists prioritize patient medication education and pharmaceutical care in routine practice to facilitate rational use of antitumor drugs in clinical settings.关键词
抗肿瘤药物/药品不良反应/回顾性分析Key words
Anti-tumor drugs/Adverse drug reactions/Retrospective analysis分类
医药卫生引用本文复制引用
赵晨,李娜,王德菊,史筱倩,杨柱梅,孔树佳..857例抗肿瘤药物所致不良反应分析[J].肿瘤药学,2025,15(4):551-558,8.
