中国中医眼科杂志2025，Vol.35Issue(10)：922-927,990,7.DOI:10.13444/j.cnki.zgzyykzz.2025.10.004
雷公藤方雾化熏蒸治疗干眼的临床疗效评价
Evaluation of the Clinical Efficacy of Nebulized Tripterygium Formula Fumigation in the Treatment of Dry Eye
摘要
Abstract
OBJECTIVE To observe the clinical efficacy of Tripterygium formula aerosol inhalation in the treatment of dry eye.METHODS A total of 44 patients(44 eyes)with dry eye who presented at Eye Hospital,China Academy of Chinese Medical Sciences from May 2022 to December 2022 were enrolled and randomly divided into a treatment group(TG)and a control group(CG),with 22 cases(22 eyes)in each group.Finally,20 cases(20 eyes)were included in each group.The treatment group received Tripterygium formula aerosol inhalation combined with 0.1%sodium hyaluronate eye drops,while the control group received placebo aerosol inhalation combined with 0.1%sodium hyaluronate eye drops.Both groups were treated for 28 days.OSDI scores,tear film breakup time(BUT),SchirmerⅠ test(SⅠT),tear meniscus height(TMH),and corneal fluorescein staining(FL)scores were measured before and after treatment in both groups.RESULTS(1)OSDI scores:OSDI scores of both groups after treatment were lower than those before treatment,and the differences were statistically significant(tTG=5.945,tCG=4.559,both P=0.000).There was no statistically significant difference in OSDI scores between the two groups after treatment(P>0.05).(2)BUT:BUT of both groups after treatment was longer than that before treatment,and the differences were statistically significant(ZTG=-3.734,P=0.000;ZCG=-3.064,P=0.002).There was no statistically significant difference in BUT between the two groups after treatment(P>0.05).(3)SⅠT:SⅠT of the treatment group after treatment was longer than that before treatment,and the difference was statistically significant(Z=3.833,P=0.000);There was no statistically significant difference in the control group before and after treatment(P>0.05).After treatment,SⅠT of the treatment group was longer than that of the control group,and the difference was statistically significant(Z=14.400,P=0.000).(4)TMH:TMH of both groups after treatment was higher than that before treatment,and the differences were statistically significant(ZTG=3.786,P=0.000;ZCG=2.093,P=0.036).There was no statistically significant difference in TMH between the two groups after treatment(P>0.05).(5)FL scores:FL scores of the treatment group after treatment were lower than those before treatment,and the difference was statistically significant(t=2.179,P=0.042).There were no statistically significant differences in FL scores in the control group before and after treatment or between the two groups after treatment(P>0.05).(6)Clinical efficacy:The total effective rate was 90.00%in the treatment group and 65.00%in the control group.There was no statistically significant difference between the two groups(P>0.05).(7)Safety evaluation:No ocular adverse reactions occurred in the tested eyes of patients in either group.CONCLUSIONS Tripterygium formula aerosol inhalation combined with 0.1%sodium hyaluronate eye drops has a positive effect on improving dry eye symptoms and can be promoted for clinical use.关键词
干眼/白涩症/雷公藤方/雾化熏蒸Key words
dry eye/Bai Se Zheng/Tripterygium formula/aerosol inhalation分类
医药卫生引用本文复制引用
李言泷,曹雯媗,吴沂旎,陈亦霞,罗悦,杨剑英,吴宁玲..雷公藤方雾化熏蒸治疗干眼的临床疗效评价[J].中国中医眼科杂志,2025,35(10):922-927,990,7.基金项目
中国中医科学院高水平中医医院课题(GSP5-78) （GSP5-78）
