中国中医眼科杂志2025，Vol.35Issue(10)：939-944,6.DOI:10.13444/j.cnki.zgzyykzz.2025.10.007
基于数据挖掘探讨高健生治疗糖尿病性黄斑水肿的用药规律
Analysis of Medication Patterns in GAO Jiansheng Treatment of Diabetic Macular Edema Based on Data Mining
摘要
Abstract
OBJECTIVE To analyze the medication patterns of GAO Jiansheng in treating diabetic macular edema(DME)using data mining technology.METHODS Medical records of DME patients treated by GAO Jiansheng at the Eye Hospital,China Academy of Chinese Medical Sciences from March 2011 to December 2019 were included.Data meeting inclusion criteria were input into Excel 2019 to establish a database.The Ancient and Modern Medical Case Cloud Platform(V2.3.5)was used to analyze frequency of Chinese medicines,properties,flavors,meridian tropism,cluster analysis,association rule analysis,and complex network analysis.RESULTS(1)Properties,flavors,and meridian tropism:A total of 151 prescriptions involving 153 Chinese medicines with a cumulative frequency of 2,110 were identified.Cold was the most frequent property(799 times,37.87%),sweet was the most frequent flavor(1,235 times,39.74%),and liver meridian was the most common meridian tropism(1,079 times,22.74%).(2)High-frequency Chinese medicines:A total of 19 medicines were used over 30 times.The top 5 were Cinnamomi cortex(140 times,92.72%),Astragali radix(138 times,91.39%),Coptidis rhizoma(137 times,90.73%),Buddlejae flos(133 times,88.08%),and Leonuri herba(129 times,85.43%).(3)Efficacy classification of high-frequency medicines:Dampness-removing medicines were most common(4 medicines,21.05%),followed by tonifying medicines(3 medicines,15.78%).(4)Cluster analysis:Prescriptions were grouped into 4 clusters with efficacies including boosting Qi and nourishing Yin to improve vision,fortifying spleen and tonifying kidney to promote diuresis and drain dampness,warming Yang and unblocking vessels to guide fire back to its origin,and activating blood to resolve stasis.(5)Association rule analysis:The top 5 strongest associations were Mume fructus-Buddlejae flos,Ligustri lucidi fructus-Leonuri herba,Mume fructus-Cinnamomi cortex,Ligustri lucidi fructus-Buddlejae flos,and Coptidis rhizoma-Cinnamomi cortex.(6)High-frequency Chinese medicines complex network analysis:The core Chinese medicines network for treating DME consists of Astragalus membranaceus,Buddleja officinalis,Cinnamomum cassia,Leonurus japonicus,Coptis chinensis,Prunus mume,and Ligustrum lucidum.CONCLUSIONS GAO Jiansheng's prescriptions for DME primarily use medicines with cold or warm properties,sweet flavor,and liver meridian tropism.The core treatment approach focuses on boosting Qi and nourishing Yin while supporting kidney's Qi transformation,often combined with activating blood,regulating Qi,fortifying spleen,and promoting diuresis based on specific conditions,demonstrating flexible and adaptive prescription strategies.关键词
数据挖掘/高健生/糖尿病性黄斑水肿/用药规律Key words
data mining/GAO Jiansheng/diabetic macular edema/medication patterns分类
医药卫生引用本文复制引用
吕玉欣,严京,刘思言,吴琦,易爽爽,吴正正..基于数据挖掘探讨高健生治疗糖尿病性黄斑水肿的用药规律[J].中国中医眼科杂志,2025,35(10):939-944,6.基金项目
中国中医科学院眼科医院高水平中医医院课题(GSP3-13,GSP2-17) （GSP3-13,GSP2-17）
