中国畜禽种业2025，Vol.21Issue(9)：29-38,10.
circRNA的生物发生机制及其对牛肉品质的调控研究进展
Research Progress on the Biogenesis Mechanism of circRNA and its Regulation on Beef Quality
摘要
Abstract
Circular RNA is a class of non-coding RNA molecules with covalently closed circular structure,which is highly conserved in evolution and shows tissue-specific expression patterns.In this paper,the biogenesis mechanism and type,regulation mechanism of circular RNA and its latest progress in the regulation of beef quality were systematically reviewed.Circular RNA regulates fat de-position and muscle development through a variety of mechanisms,thereby affecting beef yield and quality.For example,circFU10 promotes subcutaneous adipose cell proliferation and inhibits differentiation by targeting PPARGC1B;circINSR relieves the inhibi-tion of miR-15/16 on FOXO1 and EPT1 through the miRNA sponge effect,thereby inhibiting the adipogenic differentiation of in-tramuscular fat.Circ2388 promotes myoblast differentiation and promotes the recovery and regeneration of damaged muscles.cir-cRRAS2 inhibits the proliferation and apoptosis of muscle stem cells and promotes the differentiation of myoblasts into myotubes.In addition,the biogenesis mechanism of circular RNA mainly depends on its unique reverse splicing process,which is regulated by a variety of cis-regulatory elements and trans-acting factors.This paper also discusses the potential of circular RNA as a candidate functional marker for innovative molecular breeding strategies,and proposes that precise regulation of its expression network is ex-pected to achieve synergistic improvement of beef yield and quality,which provides an important theoretical basis for modern ani-mal genetic improvement.关键词
环状RNA/生物发生机制/分子特性/脂肪沉积/肌肉发育Key words
CircRNA/Mechanisms of biogenesis/Molecular properties/Fat deposition/Muscle development分类
农业科技引用本文复制引用
楚洪恩,刘源,马云..circRNA的生物发生机制及其对牛肉品质的调控研究进展[J].中国畜禽种业,2025,21(9):29-38,10.基金项目
科技创新2030-重大项目(2030ZD0404803-02) （2030ZD0404803-02）
国家自然科学基金(U22A20506、32072720) （U22A20506、32072720）
宁夏回族自治区科技创新领军人才培养项目(2020GKLRLX02) （2020GKLRLX02）
宁夏回族自治区重点研发项目(2023BCF01006) （2023BCF01006）
宁夏自然科学基金项目(2024AAC03137). （2024AAC03137）
