中山大学学报（医学科学版）2025，Vol.46Issue(5)：737-746,10.
运动调控程序性细胞死亡在肌少症防治中的研究进展
Advances on Exercise-mediated Regulation of Programmed Cell Death in the Management of Sarcopenia
摘要
Abstract
With the acceleration of global population aging,sarcopenia,characterized by a progressive loss of skeletal muscle mass,strength,and physical function,has become a major public health issue that seriously threatens the health and quality of life in older adults.The development and progression of sarcopenia involve complex,multi-level,and cross-system cellular and molecular mechanisms.Recent studies have highlighted the central role of programmed cell death(PCD)in maintaining skeletal muscle homeostasis,regulating metabolism,and mediating tissue repair.The classic forms of PCD-apoptosis,autophagy,pyroptosis,and ferroptosis-interact through critical nodes such as reactive oxygen species(ROS)accumulation,mitochondrial dysfunction,and iron homeostasis disruption,ultimately driving muscle fiber loss,functional decline,and chronic inflammation.These processes underpin the pathology of sarcopenia.Exercise,the most effective non-pharmacological intervention to date,has been shown to precisely regulate multiple PCD pathways.It improves muscle mass,strength,and metabolic stability,and delays the progression of sarcopenia.Specifically,appropriate exercise could inhibit excessive apoptosis,activate protective autophagy,alleviate NLRP3 inflammasome-mediated pyroptosis,and suppress ferroptosis by enhancing antioxidant defenses and maintaining iron homeostasis.This review systematically summarizes the roles and mechanisms of apoptosis,autophagy,pyroptosis,and ferroptosis in sarcopenia.It particularly focuses on the molecular targets and physiological effects of exercise-mediated PCD regulation.The aim is to provide theoretical and practical support for developing personalized and precision exercise interventions targeting PCD pathways for the prevention and management of sarcopenia.关键词
肌少症/程序性细胞死亡/运动干预/凋亡/自噬/焦亡/铁死亡Key words
sarcopenia/programmed cell death/exercise intervention/apoptosis/autophagy/pyroptosis/ferroptosis分类
医药卫生引用本文复制引用
史雪珂,冯晓东..运动调控程序性细胞死亡在肌少症防治中的研究进展[J].中山大学学报（医学科学版）,2025,46(5):737-746,10.基金项目
国家重点研发计划"中医药现代化"重点专项课题(2023YFC3503705) （2023YFC3503705）
